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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contribut...
This IMA Volume in Mathematics and its Applications RESOURCE RECOVERY, CONFINEMENT, AND REMEDIATION OF ENVIRONMENTAL HAZARDS contains papers presented at two successful one-week workshops: Confine ment and Remediation of Environmental Hazards held on January 15-19, 2000 and Resource Recovery, February 9-13, 2000. Both workshops were integral parts of the IMA annual program on Mathematics in Reactive Flow and Transport Phenomena, 1999-2000. We would like to thank John Chadam (University of Pittsburgh), Al Cunningham (Montana State Uni versity), Richard E. Ewing (Texas A&M University), Peter Ortoleva (In diana University), and Mary Fanett Wheeler (TICAM, The University of Texas at Austin) for ...
This is the third and final book in the series Transformative Pedagogies in Teacher Education. Like the first two books in the series it is geared towards practitioners in the field of teacher education. This third book focuses on transformative leadership in teacher education. In other words, the kind of leadership and practices that will be important and necessary to bring about the kind of changes that both teachers and students seek to improve educational outcomes for all students, but in particular Black, Indigenous and racialized students who have been traditionally underserved by the education system. Teacher leadership plays an important role in transformative educational change that...
Discovering Evolution Equations with Applications: Volume 1-Deterministic Equations provides an engaging, accessible account of core theoretical results of evolution equations in a way that gradually builds intuition and culminates in exploring active research. It gives nonspecialists, even those with minimal prior exposure to analysis, the foundation to understand what evolution equations are and how to work with them in various areas of practice. After presenting the essentials of analysis, the book discusses homogenous finite-dimensional ordinary differential equations. Subsequent chapters then focus on linear homogenous abstract, nonhomogenous linear, semi-linear, functional, Sobolev-typ...
Jim Douglas, Jr.' These proceedings reflect some of the thoughts expressed at the Oberwolfach Con ference on Porous Media held June 21-27, 1992, organized by Jim Douglas, Jr., Ulrich Hornung, and Cornelius J, van Duijn. Forty-five scientists attended the conference, and about thirty papers were presented. Fourteen manuscripts were submitted for the proceedings and are incorporated in this volume; they cover a number of aspects of flow and transport in porous media. Indeed, there are 223 individual references in the fourteen papers, but fewer than fifteen are cited in more than one paper. The papers appear in alphabetical order (on the basis of the first author). A brief introduction to each ...
The Italian school of Mathematical Analysis has long and glo rious traditions. In the last thirty years it owes very much to the scientific pre-eminence of Ennio De Giorgi, Professor of Mathemati cal Analysis at the Scuola Normale Superiore di Pisa. His fundamental theorems in Calculus of Variations, in Minimal Surfaces Theory, in Partial Differential Equations, in Axiomatic Set Theory as well as the fertility of his mind to discover both general mathematical structures and techniques which frame many different problems, and profound and meaningful examples which show the limits of a theory and give origin to new results and theories, makes him an absolute reference point for all Italian mat...
The field of control theory in PDEs has broadened considerably as more realistic models have been introduced and investigated. This book presents a broad range of recent developments, new discoveries, and mathematical tools in the field. The authors discuss topics such as elasticity, thermo-elasticity, aero-elasticity, interactions between fluids a
The main aim of this paper is to present some new and general results, ap plicable to the the equations of two phase flow, as formulated in geothermal reservoir engineering. Two phase regions are important in many geothermal reservoirs, especially at depths of order several hundred metres, where ris ing, essentially isothermal single phase liquid first begins to boil. The fluid then continues to rise, with its temperature and pressure closely following the saturation (boiling) curve appropriate to the fluid composition. Perhaps the two most interesting theoretical aspects of the (idealised) two phase flow equations in geothermal reservoir engineering are that firstly, only one component (wat...
Psychology as a discipline has been criticised for perpetuating sexism, reproducing gender inequality, and neglecting marginalised perspectives.