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Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death in the United States. Annually approximately 30,000 Americans are diagnosed with the disease and most will die from it within five years. P- creatic ductal adenocarcinoma is unique because of its late onset in age, high mortality, small tumor samples infiltrated with normal cells, and a lack of both early detection and effective therapies. Some of these characteristics have made studying this disease a challenge. Pancreatic cancer develops as a result of the accumulation of genetic alterations in cancer-causing genes, such as the oncogenes and the tumor-s- pressor genes. In the last decade, major progress has been m...
Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.
The papers collected in this volume report the results of research on issues dealing with the failure of globalization to benefit poor countries. They explain how exports could be improved for these countries and reveal the role that UK supermarkets play in African poverty.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Jews created the first comic book, the first graphic novel, the first comic book convention, the first comic book specialty store, and they helped create the underground comics (or "Comix") movement of the late '60s and early '70s. Many of the creators of the most famous comic books, such as Superman, Spiderman, X-Men, and Batman, as well as the founders of MAD Magazine, were Jewish. From Krakow to Krypton: Jews and Comic Books tells their stories and demonstrates how they brought a uniquely Jewish perspective to their work and to the comics industry as a whole. Over-sized and in full color, From Krakow to Krypton is filled with sidebars, cartoon bubbles, comic book graphics, original design sketches, and photographs. It is a visually stunning and exhilarating history.
A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease. Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing the immunohistochemica nd molecular aspects of lymphoid neoplasia. Each chapter contains an extensive array of ‘clinical vignettes’ clearly showing the application of principles and treatment techniques discussed in the chapter Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the interplay between the immune system in the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail. Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition
This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will b...