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Tuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.
This internationally renowned reference work is a fully updated and expanded second edition of the most comprehensive title available on pleural diseases. Building on the many strengths of the highly respected first edition, the book features a detailed yet lucid basic science section to support understanding of the physiological and pathophysiological mechanisms that underlie diseases of the pleura. This is followed by a wide-ranging series of clinical chapters, discussing both familiar and less common aspects of pleural diseases. Chapters in the clinical section are written in an accessible and uniform style, making extensive use of illustrative material and covering definition, incidence ...
Diseases of the pleura such as effusion, thickening, or pneumothorax are frequently encountered in the practice of medicine. Practical Thoracoscopy presents an encyclopedic approach to the use of thoracoscopy in the diag nosis and treatment of patients with pleural disease. After an initial chapter on the history of thoracoscopy, the next three chapters of the book are devoted to the general technique of performing thoracoscopy, a topic on which the team of Dr. Boutin and his colleagues write with ample experience. In these chapters they provide detailed de scriptions of how to perform the procedure and discuss the pros and the cons of the different approaches and the different equipment ava...
Completely updated and revised, Clinical Tuberculosis continues to provide the TB practitioner-whether in public health, laboratory science or clinical practice-with a synoptic and definitive account of the latest methods of diagnosis, treatment and control of this challenging and debilitating disease.New in the Fifth Edition:Gamma interferon-based
With over 10 million new TB cases and 1.6 million deaths, TB is a global health priority. Multidrug-resistant TB is of particular concern to both clinicians and national TB programmes: in 2017, there were 558 000 new rifampicin-resistant cases and 460 000 confirmed multidrug-resistant TB cases. Despite extensive investigation over the years, there is still a great deal to learn about the prevention, diagnosis and treatment of TB. This Monograph brings together chapters from global TB experts and begins with a patients’ perspective that sets the tone. The following chapters cover: the history of TB; epidemiology; strategies for control and elimination; clinical and laboratory diagnosis; imaging; treatment and drugs; TB in children and different patient populations; comorbidities; clinical cases; and much more.
Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for one in every three HIV deaths and over 300,000 in 2017 alone. The HIV epidemic has undermined tuberculosis-control efforts in many countries around the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities. The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.
Although diagnosis always begins with a careful history and physical examination and a physician is obligated to consider more than the diseased organ, testing of lung function has become standard practice to confirm the diagnosis, evaluate the severity of respiratory impairment, assess the therapy response and follow-up patients with various cardio-respiratory disorders. Ventilation, diffusion, blood flow and control of breathing are the major components of respiration and one or more of these functional components can be affected by any disorder. Frequently, no single pulmonary function test.
Asthma and allergy represent increasing problems for the actively competing athlete. The prevalence of exercise-induced asthma (EIA) has increased over the last two decades, especially amongst elite endurance athletes; it has been reported that high-level endurance training in particular may increase bronchial hyperresponsiveness (BHR) and cause inflammation in the airways. Intensive endurance training and competition, together with environmental influences, are thought to be causative factors. For winter sports, inhaled cold air represents such an environmental factor; moreover, exposure of c.
The view on treatment of patients with severe respiratory disorders in general, and of patients with severe chronic obstructive pulmonary disease in particular, has changed during the past decades. The former, often nihilistic, approach has changed into an attitude towards more active engagement in, and treatment of, severely ill patients. In this context, noninvasive ventilation (NIV) has been brought into focus as a valuable alternative treatment, both in acute respiratory failure and chronic respiratory diseases. The growing interest in NIV has been reflected in the European Respiratory Mon.