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A new edition of this practical guide for clinicians who are developing tools to measure subjective states, attitudes, or non-tangible outcomes in their patients, suitable for those who have no knowledge of statistics.
Winner 1996 Evening Standard Award for Most Promising Playwright; Winner 1996 George Devine Award for Most Promising Playwright For one week each autumn, Mick Dowd is hired to disinter the bones in certain sections of his local cemetery, to make way for new arrivals. As the time approaches for him to dig up those of his own late wife, strange rumours regarding his involvement in her sudden death seven years ago gradually begin to resurface.
This copiously annotated bibliography documents and examines the whole range of commentary on Strindberg's works and activity in many fields besides the plays for which he is internationally best known. These include his prose fiction and poetry, his work as an historian and natural historian, and his relationship to the other arts, most notably his painting. It is concerned with both lasting works of literary and dramatic criticism, as well as reviews of his books and plays in the theatre, and some more ephemeral material, all of this in several languages. Organised generically and by subject and individual work, the bibliography enables the reader to trace the changing impact of Strindberg...
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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transit...
Jeśli chcemy poprawić życie na ziemi i nasze własne, musimy znaleźć nowego przewodnika: takiego, który sprosta wyzwaniom naszych czasów i przyszłości. Stare wytyczne były w zasadzie dobre, ale ugrzęzły w skostniałych strukturach, które często prowadzą do odwrotności tego, co było pierwotnie zamierzone. Rozwój społeczeństwa sprawia, że od czasu do czasu trzeba znaleźć nową wytyczną. Aby to zrobić, musimy jednak wiedzieć, jaka była historia, jak zbudowane jest obecne społeczeństwo i jak prawdopodobnie będzie się rozwijać. Autor chce to odkryć, zwracając uwagę na następujące tematy: Informacja: prawda i kłamstwa Spiski: prawdziwe i wyimaginowane spiski R...
Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. - Accessible and current coverage of coumarin derivatives from structure to potential applications - Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure - Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields