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Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in th...
Finding new strategies for synthesizing benzimidazole derivatives and functionalizing the benzimidazole core has proved to be important due to the compound's various applications in medicine, chemistry, and other areas. The multitude of benzimidazole derivatives marketed as drugs has led to intensive research in the field for the discovery of new biologically active structures. The general applications of benzimidazole derivatives in materials chemistry, electronics, technology, dyes, pigments, and agriculture open up new research horizons. This book guides the rational design of benzimidazole derivatives synthesis with certain applications. Chapters cover such topics as therapeutic use of benzimidazole in conditions like diabetes, viruses, and parasitic diseases; X-ray crystal structure of selected benzimidazole derivatives; benzimidazole compounds for cancer therapy; and others.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
A large body of evidence shows a close link between diabetes and mental health. The spectrum of the diabetes-mental health connection ranges from common determinants to synergistic challenges in management, and to consequent health and quality of life complications and outcomes. One well-documented mental health association with diabetes is depression. Both conditions are prevalent, have been on the rise globally, and are becoming forefront priorities in the context of the COVID-19 pandemic. Current evidence and hypotheses regarding this co-morbidity encompass both physiological processes (namely disruptions in endocrinological, inflammation, and vascular pathways) and psychosocial factors (gender and socioeconomic inequality). Yet, several knowledge gaps remain. A clearer characterization of the building blocks and trajectories underlying the diabetes-depression association is essential for identifying efficacious steps that can help curb this syndemic.
This collection addresses new research and technology for increased efficiency, energy reduction, and waste minimization in mineral processing, extractive metallurgy, and recycling. Professor Patrick R. Taylor and his students have been studying these topics for the past 45 years. Chapters include new directions in: · Mineral Processing · Hydrometallurgy · Pyrometallurgy · Electrometallurgy · Metals and E waste recycling · Waste minimization (including by-product recovery) · Innovations in metallurgical engineering education and curriculum development
This Special Issue came together thanks to contributions from friends and colleagues of Prof. Bernd Giese on behalf of his 80th birthday on 2 June 2020. Reflecting on the varied interests of Bernd in all areas of chemistry, this issue contains work, including historical work, on inorganic coordination chemistry, nanomaterials, theory, and organic and radical chemistry—Bernd’s core expertise. It is wonderful that so many different publications came together from all over the world, as both review articles and original contributions, making this Special Issue worthwhile reading.
This book is a baseline reference for researchers, environmentalist, planners, policy makers as well as administrators who are concerned with the future of the planet Earth.
This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Certain types of pesticides are widely used in agriculture in all parts of the world due to their relatively low cost, broad spectrum of activity, and high efficiency. These pollutants contaminate not only the surrounding soils and water but, in many cases, also enter into the drinking water. The Handbook of Research on the Adverse Effects of Pesticide Pollution in Aquatic Ecosystems provides emerging research exploring the theoretical and practical aspects of the prevention of accumulation of toxic pollutants such as agrochemicals and organochlorine pesticides in aquatic ecosystems and applications within ecology and agriculture. Featuring coverage on a broad range of topics such as pesticide monitoring, metabolites, and risk assessment, this book is ideally designed for scientists, researchers, engineers, policymakers, agricultural specialists, industrialists, academicians, and students seeking current research on the risks of water contaminants in small ecosystems.
This book provides a comprehensive understanding of the complex relationship between microbial symbionts and plants in the era of climate change. It focuses on the plant microbiome associated with different plant organs like roots, leaves, stems, fruit, and seeds, and showcases their significant role in the enhancement of crop yield and protection in a sustainable manner. Concomitantly, acumens to the most emerging trends in plant microbial research that includes rhizosphere engineering and metagenomics are also covered in this title. The association of microbial symbionts with the host offers a wide advantage in terms of acclimatization to varied environmental conditions. A large number of ...