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"When a thing ceases to be a subject of controversy, it ceases to be a subject of interest. " WILLIAM HAZLITT (1778-1830) This is the fourth volume in a series which we started in 1997. In 1976, Varco and Delaney edited a "surgical bestseller" entitled Controversy in Surgery. This was fol lowed by a second volume in 1985. The immense success of these books among both surgical trainees and experienced surgeons, and their wide international ap peal, supported the editors' notion that a view of controversy is integral to teach ing. However, despite major advances in surgical science and practice, no other similar publication has since been put together with the objective of addressing major con...
The relationship between alcohol consumption and liver cirrhosis has long been contested by doctors and medical professionals, creating numerous implications for the public reputation of alcohol in Britain. Despite this, it was not until the 1970s that cirrhosis came to be understood as an ‘alcoholic disease’. This book contextualises developments in this debate through the twentieth century by examining the significant influence that medical expertise had on policy responses to alcohol misuse, as well as the social reputation of alcohol consumption. It demonstrates how the degree to which drinking was seen to be responsible for liver disease directly shaped how different groups, such as...
The revised fourth edition of Evidence-Based Gastroenterology and Hepatology continues to provide the most current, evidence-based information for determining the appropriate medical and surgical options for screening for, diagnosing, and treating gastrointestinal conditions. With contributions from an international team of leading experts in the field, the 4th edition includes practical recommendations for the care of individual patients based on the latest scientific evidence.
The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
This volume is the first text to concisely yet comprehensively cover developments for both alcoholic and nonalcoholic fatty liver disease in an organized fashion. Aspects of these two diseases covered in the book include global epidemiology and risk factors, pathogenesis, animal models, hepatic and extra-hepatic malignancies, treatment models, and current and emerging therapies. Written by experts in the field, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside is a valuable resource for gastroenterologists, pathologists, and hepatologists who treat patients with alcoholic and nonalcoholic fatty liver disease.
This volume presents a concise yet comprehensive overview on all facets concerning the complications of cirrhosis. Structured in three sections, the book reviews the natural history of cirrhosis, the diagnostic and predictive tools available to assess the disease, complications, and treatment options such as liver assist devices and transplantation. Topical concerns in the management of patients with cirrhosis are also addressed, including issues pertaining to the delivery of quality care in this patient population. Written by experts in their fields, Complications of Cirrhosis: Evaluation and Management serves as a valuable resource for practitioners and physicians-in-training on the subject of cirrhosis.
In this book, Chloë Rae Edmonson analyzes performance sites from throughout U.S. history to reveal the material ways that drinking culture is performative, immersive performance is intoxicating, and how alcohol shapes performance space and practice. Combining archival research with firsthand accounts of immersive spaces, this study demonstrates how social drinking and performance in themed spaces often collude to reify power dynamics latent to mainstream American culture, such as patriarchal values, racial and wealth inequality, and labor exploitation. Yet there are also examples of how performers, designers, and consumers creatively subvert such dominant attitudes in pursuit of their own c...