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Disorders of the Human Adrenal Cortex
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel 'backdoor' pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing's syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
Pediatric Adrenal Diseases
Written by experts and specialized investigators, this book presents a detailed overview of the recent progress in our understanding of the adrenal cortex and its pivotal roles in homeostasis. Genes, molecules and cell compartments directly or indirectly involved in the complex steroidogenesis pathway as well as the resulting end-hormones glucocorticoids, mineralocorticoids and androgens are analyzed. Furthermore, the defects of the genes responsible both for common and rare adrenal disorders are presented. The interactions of the adrenal cortices with the adrenal medulla and their importance in the integration of adrenocortical and adrenomedullary function are discussed. The complex molecul...
Synthetic Methods of Organometallic and Inorganic Chemistry: Phosphorus, arsenic, antimony, and bismuth
A series containing experimental procedures as a benchtop tool for preparative organometallic, inorganic and organoelement chemists.
Nano and Micro Engineered Membrane Technology
Nano and Micro Engineered Membrane Technology is about Nano and micro engineered membrane technology, an emerging new technological area in membrane technology. Potential applications cover a broad spectrum of science, such as micro and nano filtration, gas separation, optics and nanophotonics, catalysis, microbiology, controlled drug delivery, nanopatterning, micro contact printing, atomisation, cross flow emulsification, etc. A brief overview of filtration membranes and pore structures is presented in chapter 1 and in the subsequent chapter 2 an overview is presented of conventional micro perforation methods, like laser drilling, electroforming, precision etching etc. With micro engineerin...
Molecular Structures and Dimensions
This volume is the fourteenth classified bibliography of organic, organometallic and metal complex crystal structures prepared by the Cambridge Crystallo graphic Data Centre and published jointly with the International Union of Crystallography. The previous thirteen volumes covered the years 1935-81; the majority of references in the present volume pertain to structure analyses reported in the literature during 1981 and 1982. A few structures reported prior to 1981 and omitted in earlier volumes are also included. Volume 14 contains 4094 references to 4001 distinct chemical compounds with 2162 cross-references. Some 90% of these references were obtained by direct in-house scanning of 51 majo...
Male-mediated Developmental Toxicity
Germ cells have a unique and critical role as the conduit for hereditary information. The issue of male germline mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile in recent years. Understanding the mechanisms by which the germline is induced and maintained is one of the effective ways to treat infertility and cancer. Male-mediated Developmental Toxicity discusses these issues and provides analysis of the fundamental mechanisms of mutations covering both clinical and experimental aspects. It helps clarify the data explaining how genotoxicity involves multiple modes of action and highlights novel models and assays being used to assess germ cell genotoxicity. With a clear focus on the various mechanisms that could impact human health, this book is for postgraduate students and researchers in reproductive and developmental toxicology as well as those with an interest in the fields of genetically inherited diseases, developmental biology and, potentially, those with a more clinical background.
The Chemistry of Nitrogen-rich Functional Groups
Nitrogen is unique among the non-carbon atoms in its ability to form single, double, and triple bonds with itself, giving rise to a wide range of organic-chemical groups containing several nitrogen atoms in different states and geometries. The present volume surveys the properties and chemical behaviour of all important nitrogen-rich organic-chemical groups, including azides, azimines, aziridines, diazo compounds, nitramines, nitrenes, nitrosamines, polyazine N-oxides, tetrazoles, triazanes, triazenes, and triazoles. A special focus lies on commercially important species which are used, e. g., as powerful explosives. PATAI's Chemistry of Functional Groups publishes comprehensive reviews on all aspects of specific functional groups. Each volume contains outstanding surveys on theoretical and computational aspects, NMR, MS, other spectroscopic methods and analytical chemistry, structural aspects, thermochemistry, photochemistry, synthetic approaches and strategies, synthetic uses and applications in chemical and pharmaceutical industries, biological, biochemical and environmental aspects. To date, almost 150 volumes have been published in the series.
Proceedings of the Ninth International Dakhleh Oasis Project Conference
This new volume in the Oasis Papers series marks the 40th anniversary of archaeological fieldwork in the Dakhleh Oasis in Egypt’s Western Desert under the leadership of Anthony J. Mills and presents a synthesis of the current state of our knowledge of the oasis and its interconnections with surrounding regions, especially the Nile Valley. The papers are by distinguished authorities in the field and postgraduate students who specialise in different aspects of Dakhleh and presents an almost complete survey of the archaeology of Dakhleh including much unpublished, original material. It will be one of the few to document a specific part of modern Egypt in such detail and thus should have a broad and lasting appeal. The content of some of the papers is unlikely to be published in any other form elsewhere. Dakhleh is possibly the most intensively examined wider geographic region within Egypt.
Genetic Steroid Disorders
Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple metabolic processes; chiefly among them are reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs, and xenobiotics. Mutations in POR cause a complex set of disorders that often resemble defects in steroid metabolizing enzymes 17-hydroxylase, 21-hydroxylase, and aromatase. Since the initial reports of POR mutations in 2004, more than 70 different mutations and polymorphisms in the POR gene have been identified and tested for their effect on activities of several steroid and drug metabolizing P450 proteins. Mutations in POR may have variable effects on different P450 partner proteins depending on the location of the mutation. The POR mutations that disrupt the binding of cofactors have a negative impact on all partner proteins, while mutations causing subtle structural changes may lead to altered interaction with partner proteins and the overall effect may be different for each partner.
Advances in Heterocyclic Chemistry
Advances in Heterocyclic Chemistry
