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For introductory courses in Engineering Technologies Introduction to Engineering Technology, 8th Edition, explains the responsibilities of technicians and technologists in the dynamic world of engineering. The basic tools of engineering technology, including problem solving, calculator skills, conversion of units, geometry, computer skills, and technical reporting, are explained. Mathematical concepts are presented in a moderately-paced manner, including practical, worked-out examples for the engineering calculator. In addition to developing students’ skills in algebra, trigonometry, and geometry, this popular text also helps them to understand the broad spectrum of today’s technologies....
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
Many changes have taken place in the decade since Follow the Blue Blazes was first published, changes in the trails themselves and in the way we hike them. The Buckeye Trail still wends its way around the state of Ohio, following the course marked out by the characteristic blue blazes on trees and signposts along the way. In the intervening years, however, sections of the trail have changed their route, added amenities, or just grown more interesting. From the startling rock formations and graceful waterfalls of Old Man’s Cave, to Native American mounds, battlefields, and scenic rivers, Connie and Robert J. Pond provide a captivating guide to often-overlooked treasures around the state. Ea...
DIVNoted origamist presents step-by-step instructions and diagrams for 20 challenging projects: treehopper, spotted ladybug, orb weaver, tarantula, butterfly, grasshopper, dragonfly, praying mantis, more. Intermediate to advanced level. /div
Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.
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Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics
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