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Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand this pathogen and provide feasible solutions to prevent, treat and reduce E. coli infections. The Latin American Coalition for Escherichia coli Research (LACER) was created as a multidisciplinary network of international research groups working with E. coli with the ultimate goal of advancing understanding of E. coli, and to...
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
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This book details the latest R&D in electrochemical energy storage technologies for portable electronics and electric vehicle applications. During the past three decades, great progress has been made in R & D of various batteries in terms of energy density increase and cost reduction. One of the biggest challenges is increasing the energy density to achieve longer endurance time. In this book, recent research and development in advanced electrode materials for electrochemical energy storage devices is covered. Topics covered in this important book include: Carbon anode materials for sodium-ion batteries Lithium titanate-based lithium-ion batteries Rational material design and performance opt...
Contributions from 80 world-renowned authorities representing a broad international background lend Fungal Biotechnology in Agricultural, Food, and Environmental Applicationsfirst-class information on the biotechnological potential of entomopathogenic fungi and ergot alkaloids, applications of Trichoderma in disease control, and the development of mycoherbicides. Additional topics include fungal control of nematodes, control of plant disease by arbuscular mycorrhizal fungi, strategies for controlling vegetable and fruit crops, molecular biology tactics with mycotoxigenic fungi and the development of biofungicides, production of edible fungi, fermented foods, and high-value products like mycoprotein.
This book addresses the key challenges of balancing economic growth, poverty alleviation, and environmental protection in the development of major physical infrastructure, ranging from transport to energy.
The 'Red Book' is the definitive guide for scientists requiring internationally approved inorganic nomenclature in a legal or regulatory environment.
This publication deals with key issues in land tenure, especially as they relate to food insecurity and rural development situations. Land tenure issues are frequently ignored in rural development interventions, with often long-lasting, negative results. This guide is designed to assist technical officers in governments and civil society in understanding why and how land tenure issues should be considered in rural development projects. It analyses important contexts such as environmental degradation, gender discrimination, and conflicts, where land tenure is currently of critical concern.
Hans Ulrich Obrist met the great visionary and architectural theorist Cedric Price several times between 1999 and shortly before his death in 2003 and spoke with him about his architectural concepts and most important projects. The result is a spirited and vivid description of Cedric Price's life work. English text.