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Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explor...
Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
The definitive book on reverse shoulder arthroplasty from leading orthopaedic shoulder surgeons This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, R...
It's no secret that our planet—and the delicate web of ecosystems that comprise it—is in crisis. Environmental threats such as climate change, pollution, habitat loss, and land degradation threaten the survival of thousands of plant and animal species each day. In 100 Heartbeats, conservationist and television host Jeff Corwin provides an urgent, palpable portrait of the wildlife that is suffering in silence and teetering on the brink of extinction. From the forests slipping away beneath the stealthy paws of the Florida panther, to the giant panda's plight to climb ever higher in the mountains of China in search of sustenance, to the brutal poaching tactics that have devastated Africa's ...
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Build your Foundation of Basic Science – from Research to Clinical Application A great tool for MOC preparation! A 'must have' for residency! This fourth edition, developed in a partnership between the American Academy of Orthopaedic Surgeons (AAOS) and the Orthopaedic Research Society (ORS), is your concise and clinically relevant resource for the diagnosis and treatment of musculoskeletal diseases and conditions.
Takes a materials science approach, correlating structure-property relationships with function across a broad range of biological materials.
"Solidification Processing of Metal Matrix Composites" (MMCs) focuses primarily on microcomposites but also covers macrocomposites, nanocomposites and foams. There are four main areas detailed: fundamentals of solidification synthesis, which examines issues related to stir mixing, pressure infiltration, transfer of particles or fibers through gas-liquid and liquid-solid interfaces, and particle/fiber interactions with fluids; processing and microstructures, which focuses on microstructure formation during solidification of MMC under different conditions, such as nucleation, growth, heat transfer, microsegregation, macrosegregation and interactions between solidifying interfaces, particles an...
A collection of proceedings from the symposium in Honor of Drs. Gary Sandrock, Louis Schlapbach, and Sejiirau Suda. From the a href="http: //www.tms.org/Meetings/Annual-06/AnnMtg06Home.html"2006 TMS Annual Meeting, held March 12-16, 2006, in San Antonio, Texas.
These papers describe past alloy design experiences and state-of-the-art methodologies and first-principle, neural network, combinational, phase-field, thermodynamic, and regression-based alloy design.