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The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.
This volume documents the theoretical and observational results and arguments in favour of (or against) the most preferred models of structure formation. New observational results of the large scale distribution of matter are confronted with recent theories on the origin and evolution of structure in the universe.
Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
The book reports on a new methodology for optimization and evaluation of traffic safety, which simulates the processes involved in traffic conflicts on the basis of detailed dynamical, human, and technical models. The models incorporate the whole spectrum of human cognitive functions and responses, the responses of an active safety system and the interactions between the human and the system as they occur in a sample of relevant traffic contexts. Using the developed method, the author was able to assess the reduction in accidents and injuries as well as the possible side effects resulting from a preventive pedestrian-protection system. The book provides practical solutions in the area of active safety systems. It represents an interesting source of information for researchers and professionals as well as all stakeholders, including policy makers and consumer advocates, with the common goal of promoting the implementation and adoption of highly efficient systems for preventing accidents and injuries.
Examining baseball not just as a game but as a social, historical, and political force, this collection of sixteen essays looks at the sport from the perspectives of race, sexual orientation, economic power, social class, imperialism, nationalism, and international diplomacy. Together, the essays underscore the point that baseball is not just a form of entertainment but a major part of the culture and power struggles of American life as well as the nation's international footprint.
From the late 1950s to the 1980s, baseball’s American League mismanaged integration and expansion, allowing the National League to forge ahead in attendance and prestige. While both leagues had executive structures that presented few barriers to individual team owners acting purely in their own interests, it was the American League that succumbed to infighting—which ultimately led to its disappearance into what we now call Major League Baseball. Stumbling around the Bases is the story of how the American League fell into such a disastrous state, struggling for decades to escape its nadir and, when it finally righted itself, losing its independence. The American League’s trip to the bot...
WINNER OF THE 2014 SEYMOUR MEDAL sponsored by the Society for American Baseball Research and finalist for 2014 SABR Larry Ritter Award Though his pitching career lasted only a few seasons, Howard Ellsworth "Smoky Joe" Wood was one of the most dominating figures in baseball history--a man many consider the best baseball player who is not in the Hall of Fame. About his fastball, Hall of Fame pitcher Walter Johnson once said: "Listen, mister, no man alive can throw harder than Smoky Joe Wood." Smoky Joe Wood chronicles the singular life befitting such a baseball legend. Wood got his start impersonating a female on the National Bloomer Girls team. A natural athlete, he pitched for the Boston Red...
“A wealth of good ideas” for using technology in education, from increasing student engagement to managing hybrid and distance learning (Teachers College Record). How should I use technology in my courses? What impact does technology have on student learning? Is distance learning effective? Should I give online tests and, if so, how can I be sure of the integrity of the students’ work? These are some of the questions that instructors raise as technology becomes an integral part of the educational experience. In Quick Hits for Teaching with Technology, award-winning instructors representing a wide range of academic disciplines describe their strategies for employing technology to achieve learning objectives. They include tips on using just-in-time teaching, wikis, clickers, YouTube, blogging, and GIS, to name just a few. An accompanying interactive website enhances the value of this innovative tool.
This collection of fresh essays examines the intersection of baseball and social class, pointing to the conclusion that America's game, infused from its origins with a democratic mythos and founded on high-minded principles of meritocracy, is nonetheless fraught with problematic class contradictions. Each essayist has explored how class standing has influenced some aspect of the game as experienced by those who play it, those who watch it, those who write about it, and those who market it. The topic of class is an amorphous one and in tying it to baseball the contributors have considered matters of race, education, locality, integration, assimilation, and cultural standing. These elements are crucial to understanding how baseball creates, preserves, reinforces and occasionally assails class divisions among those who watch, play, and own the game.