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In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more. Contains 11 relevant, practice-oriented topics including diagnosis and differential diagnosis; red cell antigens and antibodies; traditional and novel tests; DAT neg AIHA; and more. Provides in-depth clinical reviews on new developments in the understanding and treatment of autoimmune hemolytic anemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Telecommunication has undergone unprecedented change in recent times. Two hundred years ago, Sir Francis Ronalds foresaw its development and imagined a world of "electrical conversations". His subsequent creations, the most important of which include an early version of the telegraph, have had significant impact on modern living. Little recognized until now, his extraordinary legacy is brought to life through never-before published sources written by people close to the man himself. In this book, details of Sir Francis's inventions — covering areas as diverse as electrical devices, weather forecasting, photography, art, mass production, and even fishing — are interwoven with personal and professional tales of achievement. Fresh light is shone on controversies and precedence in several important discoveries. Using both anecdotal and scientific evidence, it is written for those interested in the pursuit of science in the 19th century and the fascinating developments which have proved essential to the technological revolution of the 21st century. Read more about Sir Francis Ronald's life on Physics Today.
In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more. Contains 11 relevant, practice-oriented topics including diagnosis and differential diagnosis; red cell antigens and antibodies; traditional and novel tests; DAT neg AIHA; and more. Provides in-depth clinical reviews on new developments in the understanding and treatment of autoimmune hemolytic anemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.
This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include:...
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.