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The killer was holding Ronalds in a half nelson with a knife to his throat. He had changed his appearance, but Angelo knew who he was. She hadn't even suspected him. "Give it up!" she said, pointing her Glock at him He laughed. It was a sick, twisted laugh. He was mad, completely insane. "Let Detective Ronalds go!" He pressed the knife to her partner's exposed neck drawing blood. "Drop your weapon, bitch!" "Just shoot him!" Ronalds shouted. His voice was stern, full of authority. Dark red blood began to dribble down Ronalds' neck onto his white oxford shirt as the killer forced the knife deeper...
Telecommunication has undergone unprecedented change in recent times. Two hundred years ago, Sir Francis Ronalds foresaw its development and imagined a world of 'electrical conversations'. His subsequent creations, the most important of which include an early version of the telegraph, have had significant impact on modern living. Little recognized until now, his extraordinary legacy is brought to life through never-before published sources written by people close to the man himself.In this book, details of Sir Francis's inventions — covering areas as diverse as electrical devices, weather forecasting, photography, art, mass production, and even fishing — are interwoven with personal and professional tales of achievement. Fresh light is shone on controversies and precedence in several important discoveries. Using both anecdotal and scientific evidence, it is written for those interested in the pursuit of science in the 19th century and the fascinating developments which have proved essential to the technological revolution of the 21st century.
This book is written as a reference and guidebook for practicing surgeons, gastroenterologists, and interventional radiologists with an interest in hepatobiliary diseases. It presents a strategy to enhance surgeons practice and the care of patients.
This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.
This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include:...
In this issue of Hematology/Oncology Clinics, guest editors Drs. Matthew B. Yurgelun and Douglas A. Rubinson bring their considerable expertise to the topic of Pancreatic Cancer. Top experts in the field cover key topics such as pancreatic adenocarcinoma: trends in epidemiology, risk factors, and outcomes; decision making regarding perioperative therapy in individuals with localized pancreatic adenocarcinoma; the evolving role of radiotherapy in the management of individuals with pancreatic adenocarcinoma; and more. - Contains 14 relevant, practice-oriented topics including diabetes, cachexia, sarcopenia, and metabolic factors in individuals with pancreatic adenocarcinoma; PARP inhibitors an...
Fourteen years ago Michael dazzled the world with Ephesus, a brilliant debut novel that won him the respect of his peers, plenty of easy sex and the coveted Booker Prize. Since then, there's been nothing but false starts and dead ends. He can't even finish a short story. With debt collectors at the door, the cellar empty and the mortgage on the line, it's crunch time. His wife, Tanya, issues an ultimatum: get a job or get a divorce. Forced into assessing his literary agent's slush pile to help make ends meet, Michael discovers a dark gem. He rewrites it to make it his own. His publisher loves it and fame beckons and his literary standing soars... until the real author appears. Slush Pile is a satire of literary ambition.