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Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease
This ebook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established. Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.
English-Italian
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Drug Discovery Toxicology
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Photovoltaik Engineering
Stimmt die Peakleistung meines Solarmoduls? Lohnt sich MPP-Tracking? Wird die PV-Anlage durch den Kamin des Nachbarn abgeschattet? Die Grundlagen zur qualifizierten Beantwortung dieser Fragen werden im vorliegenden Buch ausführlich dargestellt. Insbesondere die Beschreibung des Betriebsverhaltens von Solarzellen anhand der effektiven Solarzellenkennlinie ermöglicht eine explizite Berechnung von Anpassungsproblemen im Teillastbereich. Bei der Dimensionierung von Solaranlagen im Inselbetrieb wird die zu erwartende Verfügbarkeit als Zielgröße der Dimensionierung angesetzt. Anhand von jährlichen Einstrahlungs-Statistiken kann ein Erwartungswert für die aus einer gegebenen Dimensionierung ...
The Organic Chemistry of Drug Design and Drug Action
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in che...
