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Human Pathobiochemistry
This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.
Geotechnical Design and Practice
This book presents articles covering a wide spectrum of topics in geotechnical engineering, including properties of soils, unsaturated soil mechanics, ground improvement, liquefaction and seismic studies, soil-structure interaction and stability analysis of man-made and natural slopes. The contributing authors are renowned researchers in their respective fields, which include soft ground improvement, seismic response of retaining structure using soil-structure Interaction (SSI) principles, and unsaturated soils. Based on keynote addresses and invited talks presented at the Indian Geotechnical Conference 2016, this book will prove a valuable resource for practicing engineers and researchers in the field of geotechnical engineering.
Aerosol Microphysics I
The suggestion by Dr. Franklin S. Harris, Jr. , that these books be written arose pursuant to the editor's plaints that despite the implicitly or explicitly ack nowledged importance of both aerosols and particulate matter in innumerable domains of technology and human welfare, investigations of these subjects were generally not supported independently of the narrowest conceivable domains of their appli cations. Frank Harris, who has long been a contributor in one of the important domains of aerosol macrophysics, atmospheric optics, challenged the editor to elaborate his views. Ideally, they would have taken the form of a monograph; however, there is as yet an insufficient body of information...
DNA Damage, DNA Repair and Disease Volume 1
The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
Virtual Drug Design
In the current drug research environment in academia and industry, cheminformatics and virtual screening methods are well established and integrated tools. Computational tools are used to predict a compound’s 3D structure, the 3D structure and function of a pharmacological target, ligand-target interactions, binding energies, and other factors essential for a successful drug. This includes molecular properties such as solubility, logP value, susceptibility to metabolism, cell permeation, blood brain barrier permeation, interaction with drug transporters and potential off-target effects. Given that approximately 40 million unique compounds are readily available for purchase, such computational modeling and filtering tools are essential to support the drug discovery and development process. The aim of all these calculations is to focus experimental efforts on the most promising candidates and exclude problematic compounds early in the project. In this Research Topic on virtual activity predictions, we cover several aspects of this research area such as historical perspectives, data sources, ligand treatment, virtual screening methods, hit list handling and filtering.
Handbook of Utility Theory
The standard rationality hypothesis is that behaviour can be represented as the maximization of a suitably restricted utility function. This hypothesis lies at the heart of a large body of recent work in economics, of course, but also in political science, ethics, and other major branches of the social sciences. Though this hypothesis of utility maximization deserves our continued respect, finding further refinements and developing new critiques remain areas of active research. In fact, many fundamental conceptual problems remain unsettled. Where others have been resolved, their resolutions may be too recent to have achieved widespread understanding among social scientists. Last but not leas...
Annual Report
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