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The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book: · Biological aspects of stem cell sources, differentiation and engineering. · Application of microfluidics to study stem cell dynamics · Potential clinical application of stem cells and gene therapy to specific human disease. · Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. · Biomimetic multiscale topography for cell alignment.
This hugely important volume presents in a single text many novel aspects of stem cell biology with respect to scientific endeavors and future applications. During the past few years, stem cell research has metamorphosed into distinct and specialized avenues of research. What makes this book unique is that it not only covers these varied areas of research, but examines in detail some of the key pharmacological issues that up to now have not been addressed in a single volume.
"Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potentia"
This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
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History as a social science is arguably more self-reflective than associated disciplines in that family. Other social scientists seem to see little reason to look beyond the paradigm they are developing in the present times. Historians on the other hand, tend to depend on the cumulative process of the development of their craft and the fund of accumulated knowledge. Yet, while this is acknowledged in the practice of research, Historiography in itself as a subject of study has rarely found its place in the syllabi of Indian universities. Knowledge of Historiography is taken for granted when a scholar plunges into research. In an attempt to address this lacuna, the Indian Council of Historical Research (ICHR) has planned a series of volumes on Historiography comprising articles by subject specialists commissioned by the ICHR. The first volume in the series, Approaches to History: Essays in Indian Historiography brings to the readers the first fruits of that endeavour. While the essays encompass areas of research presently at the frontiers of new research, scholars will also find the bibliographies accompanying the essays of significant appeal.
Stem cell biology has gained tremendous interest in the recent years, driven by the hope of finding cures for several diseases throughtransplantation medicine. Various types of stem cells have beenidentified from preimplantation embryos, the fetus, placenta andadult