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Advances in Cancer Research
  • Language: en
  • Pages: 233

Advances in Cancer Research

This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi et al. Review the frequent abnormalities found in the FHIT gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.

Intratumor Diversity and Clonal Evolution in Cancer
  • Language: en
  • Pages: 369

Intratumor Diversity and Clonal Evolution in Cancer

This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. - Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research - Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems - Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise

Single Cell Analysis
  • Language: en
  • Pages: 254

Single Cell Analysis

  • Type: Book
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  • Published: 2021-06-02
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  • Publisher: MDPI

Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological ...

Insall & Scott Surgery of the Knee E-Book
  • Language: en
  • Pages: 2138

Insall & Scott Surgery of the Knee E-Book

Online and in print, Insall & Scott Surgery of the Knee, edited by W. Norman Scott, MD, and 11 section editors who are experts in their fields, is your complete, multimedia guide to the most effective approaches for diagnosis and management of the full range of knee disorders affecting patients of all ages. From anatomical and biomechanical foundations, to revision total knee replacement, this authoritative reference provides the most up-to-date and complete guidance on cutting-edge surgical procedures, the largest collection of knee videos in one knee textbook. Expanded coverage and rigorous updates—including 40 online-only chapters—keep you current with the latest advances in cartilage...

Hormonal Carcinogenesis IV
  • Language: en
  • Pages: 562

Hormonal Carcinogenesis IV

It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the ...

FISH
  • Language: en
  • Pages: 308

FISH

Fluorescence in situ hybridization (known as FISH) is a well-established technique in cytogenetics that has become an important tool in general molecular and cellular biology.

Computer and Robotic Assisted Hip and Knee Surgery
  • Language: en
  • Pages: 366

Computer and Robotic Assisted Hip and Knee Surgery

The techniques of computer and robotic assisted surgery are making a major impact on the practice of orthopaedics. This book provides a complete overview of the technical and clinical aspects of computer-assisted surgery with extensive coverage of the use of robotic and navigation technologies in the surgical setting. The first part of the book presents the clinical problems and describes the basic technological components. The second part of the book describes specific applications in hip and knee reconstructive surgery.

The Pirate
  • Language: en
  • Pages: 348

The Pirate

  • Type: Book
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  • Published: 1822
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  • Publisher: Unknown

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Target Volume Definition in Radiation Oncology
  • Language: en
  • Pages: 359

Target Volume Definition in Radiation Oncology

  • Type: Book
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  • Published: 2015-04-15
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  • Publisher: Springer

The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.

Induced Effects Of Genotoxic Agents In Eukaryotic Cells
  • Language: en
  • Pages: 188

Induced Effects Of Genotoxic Agents In Eukaryotic Cells

  • Type: Book
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  • Published: 2020-07-26
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  • Publisher: CRC Press

This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.