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Valor prognóstico e preditivo da expressão imunoistoquímica de timidilato sintase em pacientes portadores de adenocarcinoma colorretal
O objetivo do estudo foi estudar a expressão de timidilato sintase (TS) como fator preditivo para eficácia de quimioterapia adjuvante com 5-fluorouracil (5-FU) e como fator prognóstico para sobrevida em pacientes portadores de câncer colorretal. Trata-se de estudo retrospectivo em uma série de 114 pacientes com carcinoma colorretal estádios II ou III, distribuídos em dois grupos: 1)cirurgia exclusiva (n=61); 2)cirurgia seguida de quimioterapia com 5-FU (n=53). A expressão de TS foi determinada por imunoistoquímica. Observou-se que a expressão intratumoral de TS foi capaz de selecionar pacientes que se beneficiaram com emprego de quimioterapia adjuvante, mas não se mostrou como variável independente para risco de recidiva ou óbito.
The Gut Microbiome in Health and Disease
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Handbook of Robotic Surgery
Handbook of Robotic Surgery serves as a primer covering the main areas of knowledge in robotic surgery. This comprehensive book provides essential information on all aspects related to robotic surgery, from the present up to the future. The discussion presented in sections ranges from the historical background of robotic surgery up to more recent and future technological innovations such as remote controls, surgically distant collaboration, simulators, modern surgical robotics, fluorescence-guided surgery, and virtual reality. The book also contains sections dedicated to the safety conditions in surgery and patient protection, which will be suitable for surgeons, health professionals, biomed...
Impact of Circulating Tumor DNA (ctDNA) in Patients with Gastrointestinal Malignancies
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Circulating Tumor Cells
The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.
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Suscetibilidade ao Câncer Colorretal em Brasileiros por Genotipagem de Polimorfismos de Nucleotídeo Único Conhecidos
Este livro trata sobre o câncer colorretal (CCR), um dos cânceres mais prevalentes no mundo, o terceiro mais comum em homens e o segundo em mulheres, sendo a quarta maior causa de mortes por câncer. As taxas de incidência do CCR vêm aumentando nos países em desenvolvimento, como o Brasil, representando a terceira neoplasia maligna mais frequente em ambos os sexos. Suas causas são multifatoriais e interdependentes, com fatores de risco genéticos e ambientais, sendo a história familial um dos principais componentes. A herdabilidade do CCR é de aproximadamente 35%, sendo que as síndromes hereditárias respondem por até 6% dos casos. Recentemente, estudos de associação em larga esc...
