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Through the use of practical examples and solutions, Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition provides the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly in clinical trials and bioequivalence studies.
As long as there have been financial markets, there have been bubbles—those moments in which asset prices inflate far beyond their intrinsic value, often with ruinous results. Yet economists are slow to agree on the underlying forces behind these events. In this book José A. Scheinkman offers new insight into the mystery of bubbles. Noting some general characteristics of bubbles—such as the rise in trading volume and the coincidence between increases in supply and bubble implosions—Scheinkman offers a model, based on differences in beliefs among investors, that explains these observations. Other top economists also offer their own thoughts on the issue: Sanford J. Grossman and Patrick Bolton expand on Scheinkman's discussion by looking at factors that contribute to bubbles—such as excessive leverage, overconfidence, mania, and panic in speculative markets—and Kenneth J. Arrow and Joseph E. Stiglitz contextualize Scheinkman's findings.
Highlighting key issues and differences among GMPs of Europe, Canada, and the WHO, this reference examines US law and governmental policy affecting domestic and multinational pharmaceutical manufacturing. The book recommend pragmatic ways to interpret and comply with FDA CGMP regulation and related criteria. They focus on geographical redistribution of manufacturing facilities, accommodation of a diversity of regulatory and statutory governance, adaptation to disparate human resources, and new growth areas of manufacture and distribution of homeopathic remedies and dietary supplements, in addition to the greater quality control required of pharmacists and other authorized dispensers.
Worlds of Dissent analyzes the myths of Central European resistance popularized by Western journalists and historians, and replaces them with a picture of the struggle against state repression as the dissidents themselves understood, debated, and lived it. In the late 1970s, when Czech intellectuals, writers, and artists drafted Charter 77 and called on their government to respect human rights, they hesitated to name themselves "dissidents." Their personal and political experiences--diverse, uncertain, nameless--have been obscured by victory narratives that portray them as larger-than-life heroes who defeated Communism in Czechoslovakia. Jonathan Bolton draws on diaries, letters, personal es...
This edition offers new and expanded information on recent developments in stability data analysis, concepts of statistical outliners, bioequivalence studies, problems in sampling and devising limits for product release, covariance analysis and tolerance intervals, multiple endpoints and clinical data analysis, and more. student price which is available upon request from Marcel Dekker.
BONUS: This edition contains a Staying True discussion guide. In this candid and compelling memoir, the first lady of South Carolina reveals the private ordeal behind her very public betrayal—and offers inspiration for anyone struggling to keep faith during life’s most trying times. She’s been a successful investment banker, a mother of four, and the campaign manager for one of American politics’ rising stars—her husband, Mark Sanford of South Carolina, once widely hailed as a possible candidate for president in 2012. Yet to most Americans, Jenny Sanford is best known for the one role she refused to play—that of conventional political spouse standing silently by while her husband...
A Wolfson History Prize Finalist A New Statesman Book of the Year A Sunday Times Book of the Year “Timely and authoritative...I enjoyed it immensely.” —Philip Pullman “If you care about books, and if you believe we must all stand up to the destruction of knowledge and cultural heritage, this is a brilliant read—both powerful and prescient.” —Elif Shafak Libraries have been attacked since ancient times but they have been especially threatened in the modern era, through war as well as willful neglect. Burning the Books describes the deliberate destruction of the knowledge safeguarded in libraries from Alexandria to Sarajevo, from smashed Assyrian tablets to the torching of the Li...
First multi-year cumulation covers six years: 1965-70.
Between 1608 and 1610 the canopy of the night sky was ripped open by an object created almost by accident: a cylinder with lenses at both ends. Galileo’s Telescope tells how this ingenious device evolved into a precision instrument that would transcend the limits of human vision and transform humanity’s view of its place in the cosmos.