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G-quadruplex and Microorganisms
G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.
Handbook of Chemical Biology of Nucleic Acids
This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Che...
G4 biology
Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Updated release includes the latest information on G4 biology
5th International Conference on Biomedical Engineering in Vietnam
This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.
Child and Adolescent Development
Global public health has improved vastly during the past 25 years, and especially in the survival of infants and young children. However, many of these children, particularly in Africa, continue to live in poverty and in unhealthy, unsupportive environments, and will not be able to meet their developmental potential. In other words, they will survive but not thrive. The UN’s Sustainable Development Goals (SDGs) stress sustainable development, not just survival and disease reduction, and the Global Strategy for Women’s, Children’s and Adolescents’ Health proposes a Survive (end preventable deaths), Thrive (ensure health and wellbeing) and Transform (expand enabling environments) agend...
Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series
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Social Register Locater
The locater lists in alphabetical order every name in all the Social registers and indicates the family's head under which it may be found and the city in which the name appears.
Spatial Cognition VII
This is the seventh volume of a series of books on fundamental research in spatial cognition. As with past volumes, the research presented here spans a broad range of research traditions, for spatial cognition concerns not just the basic spatial behavior of biological and artificial agents, but also the reasoning processes that allow spatial planning across broad spatial and temporal scales. Spatial information is critical for coordinated action and thus agents interacting with objects and moving among objects must be able to perceive spatial relations, learn about these relations, and act on them, or store the information for later use, either by themselves or communicated to others. Resear...
