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Biological Sequence Analysis
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
Digital Code of Life
A behind-the-scenes look at the most lucrative discipline within biotechnology Bioinformatics represents a new area of opportunity for investors and industry participants. Companies are spending billions on the potentially lucrative products that will come from bioinformatics. This book looks at what companies like Merck, Glaxo SmithKline Beecham, and Celera, and hospitals are doing to maneuver themselves to leadership positions in this area. Filled with in-depth insights and surprising revelations, Digital Code of Life examines the personalities who have brought bioinformatics to life and explores the commercial applications and investment opportunities of the most lucrative discipline within genomics. Glyn Moody (London, UK) has published numerous articles in Wired magazine. He is the author of the critically acclaimed book Rebel Code.
From the Sparrow's Nest
From the Sparrow's Nest is a first edition collection of the short stories and poetry of Ralph Allen. The wide range of themes, plots, and characterizations reveals the challenging experiences of the author. Most of these stories have won writing awards.
Biological Sequence Analysis
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA sequencing efforts such as the Human Genome Project. This book gives an up-to-date account with a Bayesian slant.
Out of Sight
Youth crime is simultaneously a social problem and an intrinsic part of consumer culture: while images of gangs and gangsters are used to sell global commodities, young people not in work and education are labelled as antisocial and susceptible to crime. This book focuses on the lives of a group of young adults living in a deprived housing estate situated on the edge of a large city in the North of England. It investigates the importance of fashion, music and drugs in young people's lives, providing a richly detailed ethnographic account of the realities of exclusion, and explaining how young people become involved in crime and drug use. Young men and women describe their own personal experi...
What's in Your Genome?
What’s in Your Genome? describes the functional regions of the human genome, the evidence that 90% of it is junk DNA, and the reasons this evidence has not been widely accepted by the popular press and much of the scientific community. The human genome contains about 25,000 protein-coding and noncoding genes and many other functional elements, such as origins of replication, regulatory elements, and centromeres. Functional elements occupy only about 10 percent of the more than three billion base pairs in the human genome. Much of the rest is composed of ancient fragments of broken genes, transposons, and viruses. Almost all of this is thought to be junk DNA, based on evidence that dates ba...
The Matter of Facts
How biases, the desire for a good narrative, reliance on citation metrics, and other problems undermine confidence in modern science. Modern science is built on experimental evidence, yet scientists are often very selective in deciding what evidence to use and tend to disagree about how to interpret it. In The Matter of Facts, Gareth and Rhodri Leng explore how scientists produce and use evidence. They do so to contextualize an array of problems confronting modern science that have raised concerns about its reliability: the widespread use of inappropriate statistical tests, a shortage of replication studies, and a bias in both publishing and citing “positive” results. Before these proble...
Advances in Knowledge Discovery and Data Mining
Knowledge discovery and data mining have become areas of growing significance because of the recent increasing demand for KDD techniques, including those used in machine learning, databases, statistics, knowledge acquisition, data visualization, and high performance computing. In view of this, and following the success of the five previous PAKDD conferences, the sixth Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2002) aimed to provide a forum for the sharing of original research results, innovative ideas, state-of-the-art developments, and implementation experiences in knowledge discovery and data mining among researchers in academic and industrial organizations. Muc...
Bioinformatics and Functional Genomics
The bestselling introduction to bioinformatics and functional genomics—now in an updated edition Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research. This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to ...
Database and Expert Systems Applications
This volume constitutes the refereed proceedings of the 18th International Conference on Database and Expert Systems Applications held in September 2007. Papers are organized into topical sections covering XML, data and information, datamining and data warehouses, database applications, WWW, bioinformatics, process automation and workflow, knowledge management and expert systems, database theory, query processing, and privacy and security.
