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How hormonal signals in one small structure of the brain—the hypothalamus—govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain—the hypothalamus—influences what we do, how we love, and who we are. The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
How biases, the desire for a good narrative, reliance on citation metrics, and other problems undermine confidence in modern science. Modern science is built on experimental evidence, yet scientists are often very selective in deciding what evidence to use and tend to disagree about how to interpret it. In The Matter of Facts, Gareth and Rhodri Leng explore how scientists produce and use evidence. They do so to contextualize an array of problems confronting modern science that have raised concerns about its reliability: the widespread use of inappropriate statistical tests, a shortage of replication studies, and a bias in both publishing and citing “positive” results. Before these proble...
The Neuroscience of Feelings, Emotions, and Our Darkest Impulses. This introductory text provides a detailed overview of those brains structures which control or mediate all aspects of emotion, memory, rage, violence, and sexuality: the hippocampus, amygdala, hypothalamus, and septal nuclei.
Marine fungi play a major role in marine and mangrove ecosystems. Understanding how higher fungi with their spectrum of cellulolytic and ligninolytic enzymes degrade wood tissue, while labyrinthuloids and thraustochytrids further contribute to the dissolved organic matter entering the open ocean is essential to marine ecology. This work provides an overview of marine fungi including morphology and ultrastructure, phylogeny, biogeography and biodiversity. Increasingly, biotechnology is also turning to these organisms to develop new bioactive compounds and to address problems such as decomposition of materials in the ocean and bioremediation of oil spills. These potential applications of marine fungi are also treated. In the light of massive marine oil spills in the past years, the importance of understanding marine fungi and their role in the food chain cannot be underestimated.
This book constitutes the refereed proceedings of the 4th International Conference of the CLEF Initiative, CLEF 2013, held in Valencia, Spain, in September 2013. The 32 papers and 2 keynotes presented were carefully reviewed and selected for inclusion in this volume. The papers are organized in topical sections named: evaluation and visualization; multilinguality and less-resourced languages; applications; and Lab overviews.
Electrospun Polymers and Composites: Ultrafine Materials, High Performance Fibres and Wearables reviews the latest technological developments and innovations in electrospun polymers and composites, highlighting the multifunctionality of these ultrafine materials as high performance fibers. The book's chapters investigate a wide range of different electrospinning applications, including drug delivery, tissue scaffolding, fiber reinforcement and nanofiltration, with a particular focus on shape memory effect and the wearable characteristics of electrospun polymers and composites. This will be a valuable reference resource for research and for industrial communities working in the field of electrospinning. - Covers two important material systems in electrospun materials, including electrospun polymers and composites - Emphasizes areas in shape memory effect and wearable features of electrospun polymers and composites - Presents a multidisciplinary work that will attract a wide spectrum of readers in chemical engineering, biomedical engineering, chemistry, pharmacy, environmental science, materials science and engineering, as well as mechanical and electrical engineering
The safeguarding of authentic facts is essential, especially in this disruptive Orwellian age, where digital technologies have opened the door to a post-truth world in which "alternative facts" can be so easily accepted as valid. And because facts matter, evidence matters. In this urgent manifesto, archives luminary Millar makes the case that authentic and accurate records, archives, data, and other sources of documentary proof are crucial in supporting and fostering a society that is respectful, democratic, and self-aware. An eye-opening treatise for the general public, an invaluable resource for archives students, and a provocative call-to-arms for information and records professionals, Mi...
Today there is much talk of a 'crisis of trust'; a crisis which is almost certainly genuine, but usually misunderstood. Trust: A History offers a new perspective on the ways in which trust and distrust have functioned in past society, providing an empirical and historical basis against which the present crisis can be examined, and suggesting ways in which the concept of trust can be used as a tool to understand our own and other societies. Geoffrey Hosking argues that social trust is mediated through symbolic systems, such as religion and money, and the institutions associated with them, churches and banks. Historically, these institutions have nourished trust, but the resulting trust networ...
The legendary lost Doctor Who story from the unique mind of Douglas Adams Inside this book is another book – the strangest, most important and most dangerous book in the entire universe. The Worshipful and Ancient Law of Gallifrey is one of the Artefacts, dating from dark days of Rassilon. It wields enormous power, and it must not be allowed to fall into the wrong hands. Skagra – who believes he should be God and permits himself only two smiles per day – most definitely has the wrong hands. Beware Skagra. Beware the Sphere. Beware Shada.
Neurophysiology of Neuroendocrine Neurons provides researchers and students with not only an understanding of neuroendocrine cell electrophysiology, but also an appreciation of how this model system affords access to virtually all parts of the neuron for detailed study - something unique compared to most types of neuron in the brain. Chapters range from those describing the rich history and current state of in vivo recordings, highlighting the precise relationship between the patterns of action potential discharge in these neurons and hormone release, to in vitro approaches where neuroendocrine neurons can be precisely identified and their membrane properties, morphology, and synaptic respon...