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Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.
The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.
This book is based on a unique TRIZ basics remote learning technology designed by the author. It contains more than 250 examples, assignments and solutions, and an in-depth discussion of methodological recommendations on practical implementation of theoretical postulates. It does not require any special preliminary training, and can be used by anyone who wishes to master TRIZ basics independently. The book is recommended for technical specialists, regardless of the extent of their familiarity with TRIZ, and for students in engineering.
This timely book offers a mapping of the Internet as it has developed and is used internationally, providing a lively and challenging examination of the Internet and Internet studies. There is much interest among scholars and researchers in understanding the place of the Internet in cultural, social, national, and regional settings. This is the first book-length account that not only provides a range of perspectives on the international Internet, but also explores the implications of such new knowledge and accounts for concepts, methods, and themes in Internet studies. Of special interest will be the book’s fresh and up-to-date coverage of the Internet in perhaps the most dynamic region at present: Asia-Pacific.
Fracture Behavior of Inhomogeneous Biological Materials and Interfaces Biological materials like bone, nacre, human tooth layers are inhomogeneous materials made up of soft collagen, and hard, hydroxyapatite (HAP) mineral arranged in such a fashion so that these materials have higher strength and toughness, the measure of crack resisting behavior in materials, at the same time, which is exclusive in nature for different class of materials available for different application areas. The interfaces in these biological materials are designed in such a fashion so that the load transfer between the constituents takes place so smoothly, therefore, become a region of strength, not susceptible to failure like in other man-made materials and composites. It is important to understand these aspects of biological materials so that they can be mimicked to the novel materials to satisfy the growing need of different industries
Computer Aided Innovation (CAI) is a young domain, the goal of which is to support enterprises throughout the complete innovation process. This comprehensive book presents the most up-to-date research on CAI. It addresses the main motivations of the industrial sector regarding the engineering innovation activity with computer tools and methods. The book also discusses organizational, technological and cognitive aspects of the application of CAI methods and tools.
This book constitutes the refereed proceedings of the 4th International Conference on Geometric Modeling and Processing, GMP 2006, held in Pittsburgh, PA, USA, July 2006. The book presents 36 revised full papers and 21 revised short papers addressing current issues in geometric modeling and processing are addressed. The papers are organized in topical sections on shape reconstruction, curves and surfaces, geometric processing, shape deformation, shape description, shape recognition, and more.