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Complement in Nervous System Disease
Neuroinflammation is associated with a wide spectrum of acute and chronic diseases of the central and peripheral nervous system. It causes secondary damage, which is a major determinant for progression and outcome. Activated complement is suspected to be a key player to neuroinflammation. Complement is an important evolutionary ancient system for host anti-microbial aid. It serves the innate immunity and interfaces with the adaptive immunity. Complement recognizes non-cognate or altered-self antigens and devours 'unwanted' cells or cell compartments. Activation of complement leads to opsonisation of a target, inflammation by the release of anaphylatoxins, and damage of the target by the assembled membrane attack complex. Because complement can harm self-tissue, activation is tightly controlled by regulators. However, complement activation might be excessive and uncontrolled at sites of damage contributing to neuroinflammation leading to neurodegeneration.
Structure, function, and plasticity of hippocampal dentate gyrus microcircuits
The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Several lines of evidence suggest that the dentate gyrus acts as a preprocessor of incoming information, preparing it for subsequent processing in CA3. For example, the dentate gyrus converts input from the entorhinal cortex, where cells have multiple spatial fields, into the spatially more specific place cell activity characteristic of the CA3 region. Furthermore, the dentate gyrus is involved in pattern separation, transforming relatively similar input patterns into substantially different ou...
The Cortical Neuron
To understand how the cerebral cortex functions requires knowledge of single cells in this region and of their organization into cortical networks. Looking beyond the classical "wiring diagram" description of the organization of cortical cells into circuits, this innovative work focuses ondynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical neurons--their membrane properties, their synaptic characteristics, theirfunctional connectivity, their development, and the mechanisms of their response to injury. This authoritative vo...
The Big Questions: Mathematics
The Big Questions series is designed to let renowned experts address the 20 most fundamental and frequently asked questions of a major branch of science or philosophy. Each 3000-word essay simply and concisely examines a question that has eternally perplexed enquiring minds, and provides answers from history's great thinkers. This ambitious project is a unique distillation of humanity's best ideas. In Big Questions: Mathematics, Tony Crilly answers the 20 key questions: What is maths for? Where do numbers come from? Why are primes the atoms of maths? What are the strangest numbers? Are imaginary numbers real? How big is infinity? Where do parallel lines meet? What is the maths of the universe? Are statistics lies? Can maths guarantee riches? Is there a formula for everything? Why are three dimensions not enough? Can a butterfly's wings really cause a hurricane? Can we create an unbreakable code? Is maths beauty? Can maths predict the future? What shape is the universe? What is symmetry? Is maths true? Is there anything left to solve?
The Big Questions The Universe
The Big Questions series enables renowned experts to tackle the 20 most fundamental and frequently asked questions of a major branch of science or philosophy. Each 3000-word essay simply and concisely examines a question that has eternally perplexed enquiring minds, providing answers from history's great thinkers. This ambitious project is a unique distillation of humanity's best ideas. In Big Questions: The Universe, Dr Stuart Clark tackles the 20 key questions of astronomy and cosmology: What is the universe? How big is the universe? How old is the universe? What are stars made from? How did the Universe form? Why do the planets stay in orbit? Was Einstein right? What are black holes? How did the Earth form? What were the first celestial objects? What is dark matter? What is dark energy? Are we really made from stardust? Is there life on Mars? Are there other intelligent beings? Can we travel through time and space? Can the laws of physics change? Are there alternative universes? What will be the fate of the universe? Is there cosmological evidence for God?
Psychoanalysis and Social Involvement
This book considers psychoanalysis as an ethical enterprise, both on the level of the individual in analytic psychotherapy, and on the level of society in the global struggle for human and civil rights. Hadar examines the struggle against the Israeli occupation of Palestinian lives from a Lacanian psychoanalytical perspective.
The Lateral Line System
The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information is shaped and encoded by the peripheral and central nervous systems. Contents The Gems of the Past: A...
Human Color Vision
Our understanding of human color vision has advanced tremendously in recent years, helped along by many new discoveries, ideas, and achievements. It is therefore timely that these new developments are brought together in a book, assembled specifically to include new research and insight from the leaders in the field. Although intentionally not exhaustive, many aspects of color vision are discussed in this Springer Series in Vision Research book including: the genetics of the photopigments; the anatomy and physiology of photoreceptors, retinal and cortical pathways; color perception; the effects of disorders; theories on neuronal processes and the evolution of human color vision. Several of t...
Basic Aspects of Hearing
The International Symposium on Hearing is a highly-prestigious, triennial event where world-class scientists present and discuss the most recent advances in the field of hearing research in animals and humans. Presented papers range from basic to applied research, and are of interest neuroscientists, otolaryngologists, psychologists, and artificial intelligence researchers. Basic Aspects of Hearing: Physiology and Perception includes the best papers from the 2012 International Symposium on Hearing. Over 50 chapters focus on the relationship between auditory physiology, psychoacoustics, and computational modeling.
