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Excitotoxicity in Neurological Diseases
It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die i...
Amyotrophic Lateral Sclerosis
ALS, also known as Lou Gehrig's Disease, is the most common of the motor neuron diseases that cause muscle atrophy. ALS is a chronic, progressively debilitating disease characterised by progressive muscle atrophy starting in the limbs and spreading to the rest of the body, often accompanied by overactive reflexes. It usually manifests itself after the age of 40. The exact cause of ALS is unknown and there is no cure at this time. ALS may be fatal in one year or continue for 10 or more years. This new book includes leading edge research from around the world and covers the aetiology, pathogenesis, symptoms, diagnosis, and treatment of amyotrophic lateral sclerosis (ALS).
Therapeutic Agents and Targets to Minimize Ischemic Brain Injury
BM would like to declare that he has filed patents for the application of arginine-rich peptide as neuroprotective agents for stroke and other neurological disorders. RRR patents licensed by Neuronasal Inc., a company that he also consults for and has equity interest in. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Applications of Rehabilitation Engineering Technologies for the Intervention of Neural and Motor Impairment Post Stroke
Stroke is the leading cause of disability worldwide. Stroke survivors often have motorimpairments which contribute to upper limbs dysfunctions, reduced balance, posturalcontrol and reduced mobility and proprioception. These physical symptoms lead toreduced social participation and poor quality of life. Over the past ten years, therehad been an enormous focus on the use of virtual reality (VR) and other technologiesto improve clinical outcomes for people with stroke. These technologies includelarge scale bespoke manufactured immersvie virtual reality system, or home basedrehabilitation device such as the commercially available device Nitendo Wii andMicrosoft XBox. The clinical efficacy of the...
Opportunities During Depressions
The book Opportunities During Depressions provides managers with examples and a methodology to find resilient businesses during economic crisis. Whatever their cause. During both the subprime and Covid crisis there were some highly resilient businesses: while some kept on growing, others even accelerated their growth. Thus within any industry there are some activities which constitute safe heavens companies should move into. And that happened across the economy: for instance, games and toys went from ± zero growth (in pre-crisis) to a +6% growth rate during crisis; the sports goods growth rate improved by +5%; and the production of protein crops including seeds accelerated by 11%. Furthermore, the empirical data confirms that the resilient industries and segments (among 615 in the economy) are similar between the Covid crisis (2020) and the subprime years (2008-2014). Thus, during recessions it is possible for any firm, in any industry to find safe heavens: resilient businesses to move into benefiting from marketing or/and technical synergies.
Dall'altra parte della strada
Mario Garibaldi, scrittore di fama mondiale, è alla disperata ricerca di una storia da pubblicare. In suo soccorso, in un incontro casuale, arriva il suo ex compagno di liceo Franco Taverniti, che lo introduce in una storia tremenda, tristissima e a tratti surreale, ma che è purtroppo realtà. Franco racconta al suo ex amico ciò che è accaduto nella sua vita e come forze a lui estranee lo abbiano obbligato a vivere in un incubo per oltre vent'anni. Dall'autore de "Il forestiero della vita".
