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Microenvironment-Derived Stem Cell Plasticity
Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
The Physiology of Inflammation – The Final Common Pathway to Disease
Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.
Advances in Molecular Pathology
The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by ...
Tumor Microenvironment and Metabolic Reprogramming in Cancer
Metabolic reprogramming is the hallmark of malignant tumors. Both metabolic phenotype and metabolic dependence are changed during the development of cancer from precancerous tissue to local invasion to metastasis. Cancer cells autonomously alter their flux through various metabolic pathways in order to meet the increased bioenergetic and biosynthetic demand as well as mitigate oxidative stress required for cancer cell proliferation and survival. The change of the tumor microenvironment (TME) is a key factor driving tumor metabolic reprogramming. The tumor microenvironment denotes the non-cancerous cells and components presented in the tumor, including molecules produced and released by them....
Database of Biologically Active Phytochemicals & Their Activity
Database of Biologically Active Phytochemicals and Their Activities presents an alphabetical tabulation of some 3,000 biologically active phytochemicals (elements and compounds) from higher plants. The data includes at least one and in some cases as many as 25 biological activities for each phytochemical. The database also provides data on effective dose, inhibitory concentrations, and lethal and/or toxic doses. Entries after 1990 indicate the source of the data. Database of Biologically Active Phytochemicals and Their Activities makes it possible to locate the concentration of many compounds in plants and compare this data with dosage information to calculate how much of a given plant food it would take to cause lethality, antioxidant activity, hypoglycemic activity, or artemicidal activity. Using WordPerfect (TM) 5.1's search function, you can find compounds by entering a key word in their name (e.g., choline or salicyl-), locate all compounds with a given activity (e.g., hypotensive), or list all compounds for which ED50 data is entered or reported.
Like Salt for Bread. The Jews of Bosnia and Herzegovina
A numerically small Jewish community helped their ethnically embattled neighbors in a neutral, humanitarian way to survive the longest modern siege, Sarajevo, in the early 1990s.
