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Translational ADMET for Drug Therapy
Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval
Clinical Trials Handbook
Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every...
Prodrugs
These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.
Touched by the Extraordinary
A heart-warming, inspirational collection of stories to empower, inform, soothe and entertain the reader/listener. Psychologist and researcher Apollon weaves fascinating titbits of scientific research with stunning stories from patients and her own life, of miraculous events, answered prayers, healings, animal-human interactions, synchronicities, and connections with deceased loved ones, God and angels. Learn the secret of real power: loving intention and trusting your intuition. Expect to learn how to create miracles and live joyfully.
Preclinical Safety Evaluation of Biopharmaceuticals
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the fi...
Loyalty In Death
Eve Dallas has been chosen by a deadly revolutionary group, Cassandra, as their one true adversary. While investigating the seemingly simple case of a jealous lover killing her partner, she receives a disk from Cassandra, telling her to expect a demonstration of their power. Arriving just in time to see one of her billionaire husband Roarke's empty properties blown up, the link continues as more of Roarke's city landmarks are destroyed, testing Eve and her team to the limit and costing more and more lives. Discovering that Cassandra is linked to a previous group, responsible for blowing up the Pentagon several years ago, things turn increasingly sinister as Eve realises that the murdered man and his family are implicated, and she races to break down the web of deceit and destruction before the city falls.
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