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Animal-friendly methods for rodent behavioral testing in neuroscience research
Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly c...
Neuronal cell signaling and behavior
Learning and memory functions as well as many neurodegenerative and neuropsychiatric disorders, including Parkinson’s disease, drug addiction and schizophrenia are caused by dysregulation of cell signaling mechanisms in the brain. This issue of Frontiers will provide evidence for signal transduction alterations implicated in cognitive and non cognitive behaviors, as investigated by means of pharmacological and genetic approaches. Specialists in the field will be invited to contribute articles covering the impact on behavior of manipulations of neurotransmitter systems, intracellular signaling cascades and gene expression.
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Contemporary Film Directors
Commanding a cult following among horror fans, Italian film director Dario Argento is best known for his work in two closely related genres, the crime thriller and supernatural horror. In his four decades of filmmaking, Argento has displayed a commitment to innovation, from his directorial debut with 1970's suspense thriller The Bird with the Crystal Plumage to 2009's Giallo. His films, like the lurid yellow-covered murder-mystery novels they are inspired by, follow the suspense tradition of hard-boiled American detective fiction while incorporating baroque scenes of violence and excess. This book uses controversies and theories about the films' reflections on sadism, gender, sexuality, psychoanalysis, aestheticism, and genre to declare the anti-rational logic of Argento's oeuvre. Approaching the films as rhetorical statements made through extremes of sound and vision, it places Argento in a tradition of aestheticized horror that includes De Sade, De Quincey, Poe, and Hitchcock.
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