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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease
Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Multiple System Atrophy
This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.
The Greatest Chess Queens
A total of 196 wonderful chess games played by great female chess players are illustrated in this book. They have been specifically selected to demonstrate chess openings, middle games and end games weaknesses and strengths. 160 carefully selected chess games of the current and past great female chess players in the World are included in this book. 8 fantastic games have been chosen from each of the modern greatest female chess champions. The remaining 36 games are games that include both previous and current female chess pioneers such as Vera Menchik and Susan Polgar. Each game comes with excellent instructional analysis by our Grand Chess Expert. This book is full of history and it is an excellent book for studying openings, middle games, end games and solving problems. Our Grand Chess Expert has spent quality time looking at all the different variations of all the top quality games played by our Greatest Chess Queens.
Lost in Transition
Through ethnographic essays and short stories based on her experiences in Eastern Europe between 1989 and 2009, Kristen Ghodsee explains why many Eastern Europeans are nostalgic for the communist past.
Landscape Development and Climate Change in Southwest Bulgaria (Pirin Mountains)
Landscape Development and Climate Change in Southwest Bulgaria aims to address some of the current limitations in our understanding of past Balkan climate and environment. High mountains and their ecosystems offer an outstanding opportunity for studies on the impact of climate change. The Balkan Mountains in Southeast Europe, situated at the transition between temperate and Mediterranean climate, are considered as very sensitive to historical and current global changes. The geoarchives lake sediment, peat and soil, long living trees and glaciers have been used to reconstruct the climatically-driven change of forest and treeline during the Holocene and the younger past. These processes are interrelated with complex ecological changes, as for example the seasonality of climate parameters. The landscape research approach with the analyses through multi-palaeo-geoecological proxies is new for the Balkans.
Private Equity Accounting, Investor Reporting, and Beyond
Today's only advanced comprehensive guide to private equity accounting, investor reporting, valuations and performance measurement provides a complete update to reflect the latest standards and best practices, as well as the author's unique experience teaching hundreds of fund professionals. In Private Equity Accounting, Investor Reporting and Beyond Mariya Stefanova brings together comprehensive advanced accounting guidance and advice for all private equity practitioners and fund accountants worldwide: information once available only by learning from peers. Replete with up-to-date, user-friendly examples from all main jurisdictions, this guide explains the precise workings and lifecycles of private equity funds; reviews commercial terms; evaluates structures and tax treatments; shows how to read Limited Partnership Agreements; presents best-practice details and processes, and identifies costly pitfalls to avoid.
Summary of Rob Copeland's The Fund
Get the Summary of Rob Copeland's The Fund in 20 minutes. Please note: This is a summary & not the original book. "The Fund" by Rob Copeland chronicles the journey of Katina Stefanova, from her upbringing in Communist Bulgaria to her tumultuous career at Bridgewater Associates, a hedge fund founded by Ray Dalio. Stefanova, after facing rejection, joins Bridgewater and rises through the ranks, embracing its culture of radical honesty. However, she eventually suffers a breakdown, exacerbated by Dalio's manipulative use of her recorded confrontation as a teaching tool...
Research in Computer Science in the Bulgarian Academy of Sciences
This book is a collection of papers devoted to the emergence and development in Bulgarian Academy of Sciences of some of the areas of informatics, including artificial intelligence. The papers are prepared by specialists from the Academy, some of whom are among the founders of these scientific and application areas in Bulgaria and in some cases – in the world. The book is interesting for specialists in informatics and computer science and researchers in history of sciences.
Quaternary Vegetation Dynamics of Europe
Based on palaeoecological studies by many authors, this book gives an overview of the changing history of the European plant cover during the past 2.6 million years, characterized by numerous cold and warm periods. The period of the last 20 000 years (from the Last Glacial Maximum to the present) is presented in detail, with special emphasis on the vegetation dynamics of Europe, the history of selected woody plants, the development of lakes and bogs and the emergence of European cultural landscapes under the influence of humans over thousands of years. In the analysis of the glacial and interglacial periods, the focus is on the different vegetation developments and the progressive impoverish...
Handbook of Atypical Parkinsonism
Improved diagnostic sophistication is increasingly enabling neurologists to differentiate between Parkinson's disease and other atypical parkinsonism (AP), such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The Handbook of Atypical Parkinsonism is a comprehensive survey of all diseases of this category, providing an authoritative guide to the recognition, diagnosis and management of these disorders. Each chapter follows a common structure, commencing with the full basic science of the disorder under consideration, followed by descriptions of the clinical picture and differential diagnosis. Subsequent chapters discuss current and future therapeutic approaches to these difficult conditions. Written and edited by leading practitioners in the field, clinicians in neurology and other specialties will find this book essential to the understanding and diagnosis of this complex group of disorders.
