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Information is easy. Understanding is hard. From incomprehensible tax policies to confusing medical explanations, we're swamped with information that we can'’t make sense of. Figure It Out shows us how to transform information into better presentations, better meetings, better software, and better decisions. So take heart: under the guidance of Anderson and Fast, we can, in fact, figure it out—for ourselves and for others.
There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in...
Territorial Court, Arizona, 1905 Fledgling defense attorney Owen Bartlett understands that this murder trial, against a seasoned prosecutor, is way over his head. Having come west to leave his past behind, he planned to build a new life in this wild, open land. But with only a law degree from the Boston YMCA and no courtroom experience, he has been roped into defending a man accused of murder. Now he faces a jury of ranchers, storekeepers, miners-men with little love for Mexicans like Owen's client, Miguel Cordero. If he fails, Miguel will hang. Behind Owen is Miguel's wife, Gabby, her future too in Owen's hands. In the rear of the courtroom, the widow Eva Downing listens, her heart in her t...
What happens when you’ve built a great website or app, but no one seems to care? How do you get people to stick around long enough to see how your service might be of value? In Seductive Interaction Design, speaker and author Stephen P. Anderson takes a fresh approach to designing sites and interactions based on the stages of seduction. This beautifully designed book examines what motivates people to act. Topics include: AESTHETICS, BEAUTY, AND BEHAVIOR: Why do striking visuals grab our attention? And how do emotions affect judgment and behavior? PLAYFUL SEDUCTION: How do you create playful engagements during the moment? Why are serendipity, arousal, rewards, and other delights critical to...
In A-Morphous Morphology, Stephen Anderson presents a theory of word structure which relates to a full generative grammar of language. He holds word structure to be the result of interacting principles from a number of grammatical areas, and thus not localized in a single morphological component. Dispensing with classical morphemes, the theory instead treats morphology as a matter of rule-governed relations, minimizing the non-phonological internal structure assigned to words and eliminating morphologically motivated boundary elements. Professor Anderson makes the further claim that the properties of individual lexical items are not visible to, or manipulated by, the rules of the syntax, and assimilates to morphology special clitic phenomena. A-Morphous Morphology maintains significant distinctions between inflection, derivation, and compounding, in terms of their place ina grammar. It also contains discussion of the implications of this new A-Morphous position analysis of word structure.
Inquiry, Data, and Understanding is a reflective collection of papers in which Lorin Anderson offers his personal perspective on developments in educational research over thirty years. Following an introductory chapter, in which educational research is defined as disciplined inquiry, the remaining chapters are divided into four sections: time and learning, factors influencing educational effectiveness, international perspectives, and the nature and purpose of educational research. Each section contains an introduction that places the chapters in that section in a historical and personal context. The fourth section, which concludes the book, summarises four lessons that were learned about becoming a researcher. Based on these lessons, the final chapter describes four needs that must be met if school and classroom research is to move forward: * The need for concept-based research * The need to put students back into the equation * The need to stop focusing on correlates of student achievement * The need for research on alterable variables.
This book is the result of research from over fifteen countries, asking which background and environmental factors influence achievement in mathematics and science. This research is based on data from the Third International Mathematics and Science Study (TIMSS), which was conducted under the auspices of the International Association for the Evaluation of Educational Achievement (IEA) in 1995 and 1998. In many countries researchers have started secondary analysis of the data in search for relationships between contextual factors and achievement. In these analyses two different approaches can be distinguished, which can be characterised by the metaphors of ‘fishing’ and ‘hunting’. In the ‘fishing’ approach, researchers begin with an open mind, considering all possible context variables as potentially influential. Applying analysis techniques such as regression analysis, Lisrel, PLS, HLM, and MLN, they then identify important factors within their countries or across a number of countries. In the ‘hunting’ approach, researchers hypothesise certain context variables and trace the effect of these variables on mathematics and/or science achievement.
It was the most brutal murder in the history of Coffey County, Kansas. On May 30, 1925, Florence Knoblock, a farmer's wife and the mother of a young boy, was found slaughtered on her kitchen floor. Several innocent men were taken into custody before the victim's husband, John, was accused of the crime. He would endure two sensational trials before being acquitted. Eighty years later, local historian Diana Staresinic-Deane studied the investigation, which was doomed by destroyed evidence, inexperienced lawmen, disappearing witnesses, and a community more desperate for an arrest than justice. She would also discover a witness who may have seen the murderer that fateful morning.