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This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids and features contributions from some of the leading laboratories. The chapters span three key topics: the metabolism of inositol phosphates and identification of proteins that interact with polyphosphorylated phosphatidylinositols; the mechanisms and structure of phosphatidylinositol-specific phospholipase C; and the synthesis and biological properties of analogs for phosphoinositides.
Amplification and desensitization are recognized phenomena in signal transduction systems. This study has been designed to inform biochemists, pharmacologists and other experimental biologists interested in cellular signalling systems.
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
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List of fellows in no. 1- .
The tradition known as the Path with the Result, or Lamdre, is the most important tantric system of meditation practice and theory in the Sakya school of Tibetan Buddhism. This volume contains an unprecedented compilation of eleven vital works from different periods in the history of the Path with the Result in India and Tibet, including the Vajra Lines of the great Indian adept Virupa (ca. seventh-eighth centuries), the basic text of the tradition. The collection also includes six writings by Jamyang Khyentse Wangchuk (1524-68) and an instruction manual composed by the Fifth Dalai Lama (1617-62). None of the works in this book have ever been published before in any European language, and most of these writings traditionally have been considered secret. The present translation, an important new volume of the Library of Tibetan Classics, has been made with the personal approval and encouragement of His Holiness Sakya Trizin, head of the Sakya tradition. Students of the Lamdre will rejoice at the availability and lucidity of this major translation of key Sakya texts.