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Atlas of Inherited Retinal Diseases
This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.
Precision Medicine, CRISPR, and Genome Engineering
This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.
Stem Cell Biology and Regenerative Medicine in Ophthalmology
Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease. What future directions will stem cell research take? Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.
CRISPR Genome Surgery in Stem Cells and Disease Tissues
CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy
If China Attacks Taiwan
This is a new analysis of the key issues facing Chinese policy makers in their approach towards Taiwan. This is one of the most tense and potentially explosive relationships in world politics. This book explains succinctly the impetus, the methods and the consequences if China is to use force, a prospect that has become greater following the return of President Chen Shui-bian to power in Taiwan for a second term in 2004. If China Attacks Taiwan shows how in reality there can be no real winner in such an eventuality and how the consequences would be dire not just for Taiwan and China, but East Asia as a whole. Whether China will use force depends ultimately on how its policy making apparatus ...
War and Faith
"During the sengoku era--the period of ""warring provinces"" in fifteenth- and sixteenth-century Japan--warlords vied for supremacy and sought to expand their influence over the realm. Powerful religious institutions also asserted their military might by calling upon their adherents to do battle against forces that threatened their spiritual and secular interests. The Honganji branch of Jodo Shinshu (True Pure Land Sect) Buddhism was one such powerhouse that exercised its military will by fanning violent uprisings of ikko ikki, loosely structured ""leagues of one mind"" made up of mostly commoners who banded together to fight for (or against) any number of causes--usually those advanced by t...
Musical Networks
This volume presents the most up-to-date collection of neural network models of music and creativity gathered together in one place. Chapters by leaders in the field cover new connectionist models of pitch perception, tonality, musical streaming, sequential and hierarchical melodic structure, composition, harmonization, rhythmic analysis, sound generation, and creative evolution. The collection combines journal papers on connectionist modeling, cognitive science, and music perception with new papers solicited for this volume. It also contains an extensive bibliography of related work. Contributors Shumeet Baluja, M.I. Bellgard, Michael A. Casey, Garrison W. Cottrell, Peter Desain, Robert O. Gjerdingen, Mike Greenhough, Niall Griffith, Stephen Grossberg, Henkjan Honing, Todd Jochem, Bruce F. Katz, John F. Kolen, Edward W. Large, Michael C. Mozer, Michael P.A. Page, Caroline Palmer, Jordan B. Pollack, Dean Pomerleau, Stephen W. Smoliar, Ian Taylor, Peter M. Todd, C.P. Tsang, Gregory M. Werner
Unwinding the Belly
Addressing a wide range of conditions, including digestive problems, anxiety, and depression, this handy guide helps readers reclaim basic health by using proven techniques to reconnect with their bodies. The authors show how to tap into the body/spirit's intuitive center and perform simple, quick exercises to heal. Twenty-seven line drawings and 11 photographs simplify the process, and gentle humor offers encouragement. From the Trade Paperback edition.
Understanding China's Legal System
Annotation View the Table of Contents .nbsp;nbsp;nbsp;Read the Introduction .>
Competitive Authoritarianism
Based on a detailed study of 35 cases in Africa, Asia, Latin America, and post-communist Eurasia, this book explores the fate of competitive authoritarian regimes between 1990 and 2008. It finds that where social, economic, and technocratic ties to the West were extensive, as in Eastern Europe and the Americas, the external cost of abuse led incumbents to cede power rather than crack down, which led to democratization. Where ties to the West were limited, external democratizing pressure was weaker and countries rarely democratized. In these cases, regime outcomes hinged on the character of state and ruling party organizations. Where incumbents possessed developed and cohesive coercive party structures, they could thwart opposition challenges, and competitive authoritarian regimes survived; where incumbents lacked such organizational tools, regimes were unstable but rarely democratized.
