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A frightening suspense novel about nine-year-old Trisha, who becomes lost in the woods as night falls.
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Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter like role in vascular endothelium, a scond-messenger role in N-methyl-D-aspartate (NMDA) responsive neurons in the central nervous system (CNS), a neurotoxic role after its release from these neurons, and a cytotoxic role after its release by macrophages. This volume reviews among other topics the basic chemistry and physical properties of S-nitrosothiols (RS-NO) and their biochemical mechanisms of action, NO synthase isozymes, NO synthase structure, mechanisms of NO synthesis, regulation of NOS expression and posttranslational modification, and mechanisms involving NO of CNS's damage in virus infections.
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Books on both chicken immunology and developmental biology are rare. This one, however, summarizes all aspects of both areas and therefore represents a valuable compendium for experienced researchers as well as for all newcomers to the field. Following a lengthy discussion of the origin of hemopoietic cells, regulatory elements for the differentiation of these cells and B and T cell lymphopoiesis, the book goes on to describe the generation of transgenic chickens as well as an additional basic feature in embryogenesis: the positioning of organ anlage, e.g. the limb bud. To round off, a valuable compilation of monoclonal antibodies further enhances the practical usefulness of this important book.
In A Place Called Appomattox, William Marvel turns his extensive Civil War scholarship toward Appomattox County, Virginia, and the village of Appomattox Court House, which became synonymous with the end of the Civil War when Robert E. Lee surrendered to Ulysses S. Grant there in 1865. Marvel presents a formidably researched and elegantly written analysis of the county from 1848 to 1877, using it as a microcosm of Southern attitudes, class issues, and shifting cultural mores that shaped the Civil War and its denouement. With an eye toward correcting cultural myths and enriching the historical record, Marvel analyzes the rise and fall of the village and county from 1848 to 1877, detailing the domestic economic and social vicissitudes of the village, and setting the stage for the flight of Lee’s Army toward Appomattox and the climactic surrender that still resonates today. Now available for the first time in paperback, A Place Called Appomattox reveals a new view of the Civil War, tackling some of the thorniest issues often overlooked by the nostalgic exaggerations and historical misconceptions that surround Lee’s surrender.
Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacolog...
It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed...