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Drug-like Properties: Concepts, Structure Design and Methods
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacol...
Skyscrapers
An investigation of thirty skyscrapers from around the world--both recently built and under construction--that explains the structural principles behind their creation
Topology Optimization in Engineering Structure Design
Topology Optimization in Engineering Structure Design explores the recent advances and applications of topology optimization in engineering structures design, with a particular focus on aircraft and aerospace structural systems.To meet the increasingly complex engineering challenges provided by rapid developments in these industries, structural optimization techniques have developed in conjunction with them over the past two decades. The latest methods and theories to improve mechanical performances and save structural weight under static, dynamic and thermal loads are summarized and explained in detail here, in addition to potential applications of topology optimization techniques such as s...
Temporary Structure Design
A comprehensive guide to temporary structures in construction projects Temporary Structure Design is the first book of its kind, presenting students and professionals with authoritative coverage of the major concepts in designing temporary construction structures. Beginning with a review of statistics, it presents the core topics needed to fully comprehend the design of temporary structures: strength of materials; types of loads on temporary structures; scaffolding design; soil properties and soil loading; soldier beam, lagging, and tiebacks; sheet piling and strutting; pressure and forces on formwork and falsework; concrete formwork design; falsework; bracing and guying; trestles and equipm...
Design of Ship Hull Structures
In this book, the four authors show us the condensed experience how to design ship hull structures from a practical viewpoint. In three parts, the book presents the fundamentals, the theory and the application of structural design of hulls. The topics are treated comprehensively with an emphasis on how to achieve reliable and efficient ship structures. The authors have in particular introduced their experiences with the rapid increase of ship sizes as well as the introduction of ship types with a high degree of specialization. The associated early failures of these "new" structures have been analyzed to provide the readers with illustrations why structural design needs to be carried out on several levels in order to ensure that correct loading is applied and that local structural behaviour in properly understood.
Design Structure Matrix Methods and Applications
An introduction to a powerful and flexible network modeling tool for developing and understanding complex systems, with many examples from a range of industries. Design structure matrix (DSM) is a straightforward and flexible modeling technique that can be used for designing, developing, and managing complex systems. DSM offers network modeling tools that represent the elements of a system and their interactions, thereby highlighting the system's architecture (or designed structure). Its advantages include compact format, visual nature, intuitive representation, powerful analytical capacity, and flexibility. Used primarily so far in the area of engineering management, DSM is increasingly being applied to complex issues in health care management, financial systems, public policy, natural sciences, and social systems. This book offers a clear and concise explanation of DSM methods for practitioners and researchers.
Structure and Form in Design
This book provides a critical examination of structure and form in design, covering a range of topics of great value to students and practitioners engaged in any of the specialist decorative arts and design disciplines. The complexities of two-dimensional phenomena are explained and illustrated in detail, while various three-dimensional forms are also discussed. In the context of the decorative arts and design, structure is the underlying framework, and form the resultant, visible, two- or three-dimensional outcome of the creative process. Whether hidden or visually detectable in the final design, structure invariably determines whether or not a design is successful in terms of both its aesthetics and its practical performance. Hann successfully identifies various geometric concepts, and presents and discusses a number of simple guidelines to assist the creative endeavours of both accomplished and student practitioners, teachers and researchers.
Stitch and Structure
An essential book for any textile artist looking to expand their repertoire into two- and three-dimensional work. Leading textile artist, teacher and examiner Jean Draper takes you through the entire process from designing through construction to embellishment with mixed media. This beautiful and very practical book includes diagrams, detailed drawings and stitch information to guide the reader through the techniques, which include hand and machine embroidery. It covers: Design, including recording information for translation into stitch (with lots of drawing tips); Choice of Threads, including some unusual threads and customizing them; Constructing with Thread, everything from knotted forms, with decorative threads, grids and stacks, and coiled structures; Stitches in Thin Air, constructing with stitch alone using moulds and soluble fabric; Using Mixed Media in Stitched Structures, such as paper, sticks, wire and plastics; Adding Structure to an Existing Fabric; Three-Dimensional Fabric Structures. Working in two and three-dimensions is a growing genre of textile art and this incorporates a fresh approach and great design advice.
