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Presynaptic Terminals
This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neur...
Modulation of Presynaptic Calcium Channels
This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.
Secretory Systems and Toxins
This volume deals with the relationships between toxins and one of the most fundamental processes in any living cell - the secretory cycle. The reader will find up-to-date information on secretion, generated by experts in this fast evolving field. In the last decade extensive molecular and cellular studies have exposed the molecular similarity among most known secretory systems. In this book secretion is discussed from its basic mode found in yeast up to its most sophisticated version in neurotransmitter release in nerve terminals. A comprehensive view on the mode of action of toxins which block secretion but also those which cause hyper-activation of exocytosis is provided. This book addresses the issue of toxin action by deciphering the molecular and cellular basis of exocytosis in various organisms and cellular contents.
Catecholamine Research
This book is based on invited presentations at the Ninth International Catecholamine Symposiwn. Over several decades, each International Catecholamine Symposiwn (ICS) has provided a uniquely important forwn for updating basic as well as clinical research on the catecholamines, dopamine, norepinephrine, and epinephrine. The first ICS took nd n1 place in Bethesda, Maryland, in the USA in 1958; the 2 in Milan, Italy in 1965; the 3 th in Strasbourg, France in 1973; the 4th in Asilomar, California, USA in 1978; the 5 in th th Goteborg, Sweden in 1983; the 6 in Jerusalem, Israel,in 1987; the 7 in Amsterdam, th Netherlands in 1992; and the 8 in Asilomar, California, USA in 1996. th The 9 Internatio...
Physiology of Neurons
Thanks to tremendous technical advances in molecular biology and cellular imaging after those in electrophysiology, there is now a deep understanding of the physiology of nerve cells and their synaptic interconnections. The complexity of the brain emerges from the communication and interaction between billions of these elements. This book explores systematically and didactically the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Readers of the book will be fully equipped to understand the functions and possibilities of the key units of the brain’s parallel computations.
