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"Science, Gender, and Power: Women Scientists Who Defied the Odds" is a compelling and inspiring book that chronicles the extraordinary lives and groundbreaking achievements of female scientists throughout history. From Ada Lovelace, the world's first computer programmer, to Rosalind Franklin, whose work was essential to the discovery of DNA's structure, the book showcases the remarkable contributions of women in science. It highlights their tenacity, resilience, and courage in a male-dominated field, where they often faced discrimination, sexism, and biases. Written by Ann Hibner Koblitz, a renowned historian of science and gender, the book offers an in-depth analysis of the social and cult...
The MIT Sloan School of Management, as conceived by the legendary General Motors chairman Alfred P. Sloan, was founded in 1952 to draw on the scientific and technical resources of MIT and approach the problems of management with the rigorous research practices for which MIT was famous. Fifty years later, the Sloan School gathered international leaders in business and management, MIT faculty, students, and alumni to address again the basic principles that should guide business and management. This book presents the papers prepared by student-faculty teams, speeches by business and world leaders, and summaries of the discussions from this special convocation; taken together, they offer a guide...
Grieving for their dead mother, twelve-year-old James and his younger sister Sary find healing in their affection for a stray dog.
The first global study by a historian to fully integrate the earth-system approach of the new climate science with the material history of humanity.
Most organisms and populations have to cope with hostile environments, threatening their existence. Their ability to respond phenotypically and genetically to these challenges and to evolve adaptive mechanisms is, therefore, crucial. The contributions to this book aim at understanding, from a evolutionary perspective, the impact of stress on biological systems. Scientists, applying different approaches spanning from the molecular and the protein level to individuals, populations and ecosystems, explore how organisms adapt to extreme environments, how stress changes genetic structure and affects life histories, how organisms cope with thermal stress through acclimation, and how environmental and genetic stress induce fluctuating asymmetry, shape selection pressure and cause extinction of populations. Finally, it discusses the role of stress in evolutionary change, from stress induced mutations and selection to speciation and evolution at the geological time scale. The book contains reviews and novel scientific results on the subject. It will be of interest to both researchers and graduate students and may serve as a text for graduate courses.
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized tha...
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
In this beautifully written book, North T. Cairn reflects on her three extended summer stays on Monomoy, an island wildlife sanctuary. Residing alone in an abandoned lighthouse-keeper's cottage, she lived simply in the wilderness, studying the diverse habitats of the refuge and its creatures. Cairn recalls her sojourns on Monomoy, seamlessly blending memoir with natural and social history to trace the transformations that come from encounters with nature and its inhabitants. Her evocative observations of the barrier island paradise-sea and sand, light, flora, migrating birds, white-tailed deer, gray and harbor seals-echo larger, transcendent issues of life in a changing world. For Cairn, the outer world of nature also becomes a metaphor for the inner world of reflection, new discoveries, and healing, particularly of her own childhood trauma and long estrangement from family. By Monomoy Light will reawaken the reader to the necessities of rest and peace; of space apart for meditative listening and quiet; of the imperative to preserve the character of the wilderness, wherever it may be found.
This book provides a comprehensive and critical review of the work and advancements made so far in the field of microbial physiology. It is divided into five chapters and contains comprehensive information on topics such as bacterial virulence, mechanisms and regulation, bioluminescence, and heat shock proteins, among others. This book shall be of great use to students, research scholars, and teachers pursuing their career in the fields of microbiology, medical sciences and life sciences.