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Science, Gender, and Power: Women Scientists Who Defied the Odds
"Science, Gender, and Power: Women Scientists Who Defied the Odds" is a compelling and inspiring book that chronicles the extraordinary lives and groundbreaking achievements of female scientists throughout history. From Ada Lovelace, the world's first computer programmer, to Rosalind Franklin, whose work was essential to the discovery of DNA's structure, the book showcases the remarkable contributions of women in science. It highlights their tenacity, resilience, and courage in a male-dominated field, where they often faced discrimination, sexism, and biases. Written by Ann Hibner Koblitz, a renowned historian of science and gender, the book offers an in-depth analysis of the social and cult...
Self-Perpetuating Structural States in Biology, Disease, and Genetics
Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the...
Heat Shock
During the last years the heat shock response has been stu- died as a model system to analyze control mechanisms regula- ting the synthesis of heat shock proteins providing impor- tant general insight into the regulation of gene expression. But the major revelation, which has sparked interest from all quarters of biology, is the discovery that heat shock proteins play major roles in an extraordinary variety of normal cellular processes. They are the focus of investiga- tions in many areas of cell biology, including protein traf- ficking, signal transduction, DNS replication, transcrip- tion, protein synthesis, and in the assembly of di- verse protein structures. These aspects are thoroughly trea- ted in the book, as are the implications in immunology, in- fec- tious diseases, chronic degeneration, hyperthermia, and can- cer research.
Climate Change and the Course of Global History
The first global study by a historian to fully integrate the earth-system approach of the new climate science with the material history of humanity.
Management
The MIT Sloan School of Management, as conceived by the legendary General Motors chairman Alfred P. Sloan, was founded in 1952 to draw on the scientific and technical resources of MIT and approach the problems of management with the rigorous research practices for which MIT was famous. Fifty years later, the Sloan School gathered international leaders in business and management, MIT faculty, students, and alumni to address again the basic principles that should guide business and management. This book presents the papers prepared by student-faculty teams, speeches by business and world leaders, and summaries of the discussions from this special convocation; taken together, they offer a guide...
HSF1 and Molecular Chaperones in Biology and Cancer
Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the ma...
Wander
Grieving for their dead mother, twelve-year-old James and his younger sister Sary find healing in their affection for a stray dog.
The NIH Record
None
Intracellular Traffic and Neurodegenerative Disorders
Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
