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Alleviating Stress of the Soldier and Civilian
Initially, the author intended to write a book entitled "Alleviating Stress of the Soldier". However, after going through the extensive literature and recalling his childhood memories of war times, he decided to write "Alleviating Stress of the Soldier and Civilian". Sufficient historical evidence indicates that both soldiers as well as civilians have faced the war and tolerated its deleterious consequences simultaneously. However, a soldier and his/her family face unexpected and unpredictable stresses requiring: physical and mental fitness, character, dedication, commitment, communication, mutual understanding, adjustment, discipline, tolerance, patience, isolation, resilience, hyper-vigila...
Progress in PET Radiopharmaceuticals (quality Control and Theranostics)
This book describes classical and potential PET radiopharmaceuticals (PET-RPs) which can provide high-resolution 5D images in-vivo to simultaneously diagnose and treat the patient. This novel (theranostic) approach avoids futile therapies, unnecessary radiation exposure, and saves a lot of time, money, and energy. The most significant challenge is to properly build Cyclotron & PET RPs labs. Existing books offer insufficient knowledge to accomplish the full potential of these highly specialized, expansive, and sophisticated labs, demanding in-depth knowledge, confidence, cooperation, a mutual understanding, adjustment, time management, team effort, patience, resilience, and dedication. A syst...
Monoamine Oxidase Inhibitors
This book provides basic and applied knowledge about monoamine oxidase inhibitors (MAOIs), their classification, and clinical application as neuroprotective agents and will be a valuable source of new knowledge for doctors, patients, medical students, teachers, researchers, and basic biomedical scientists interested in learning the appropriate clinical application of MAOIs without any misunderstanding for the prevention and/or treatment of neurological and neuropsychiatric disorders. The book will be of immediate interest to patients suffering from Parkinson's disease (PD), Alzheimer's disease (AD), post-traumatic stress disorders (PTSD), panic disorders, attention deficit hyperactivity diso...
Zika Virus Disease
The author was motivated to write this important book because currently there is no systematically-written document on the ZIKV disease, which could serve at this crucial moment as a textbook for medical students, physicians, nurses, and other healthcare providers as well as a reference book for basic researchers, professors, and the general public. The original concept of ZIKV-Charnolopathy due to compromised mitochondrial bioenergetics in highly vulnerable (neural progenitor cells, spermatocytes, oocytes etc.) cells and its amelioration by physiological and/or pharmacological interventions is based on years of research experience. This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilisers as promising charnolopharmacotherapeutics. They are meant to aid in the prevention and treatment of the ZIKV-linked diversified spectrum of neurodevelopmental anomalies (embryopathies) in newborn infants and Guillain Barre Syndrome (GBS) in adults. Clinical management of ZIKV-induced GBS employing IV immunoglobulin and plasmapheresis (plasma exchange) is also described.
Fetal Alcohol Spectrum Disorders
Alcoholism exerts a high genetic as well as epigenetic load and may be regarded as one of the most prevalent, identifiable, and preventable neuropsychiatric illnesses afflicting modern society today. Alcohol constituted 3.2% of all worldwide deaths in the year 2006 and is associated with >60 diseases, including foetal alcohol spectrum disorder (FASD), cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders and life-threatening injuries. Fatal alcohol spectrum disorder (FASD) is a collective term representing foetal abnormalities associated with maternal alcohol abuse. FASD is a devastating developmental disorder resulting from alcohol exposure during foetal development....
Beyond Diet and Depression
Depression is a complex global health challenge with considerable economical and psychological burden. Women, adolescents, and aging subjects are highly vulnerable to suffer from depression. Depression is linked to numerous modifiable and non-modifiable risk factors. Its effective treatment involves both psychotherapy and/or chemotherapy. Currently available pharmacotherapeutical agents used for the treatment of depression have a low margin of safety and reduced therapeutic index with deleterious adverse effects including osteoporosis, obesity, hypertension, diabetes, cardiovascular diseases, infertility and even fatalities if abused. It is now realized that a healthy life style and consuming diets rich in Mediterranean component can ameliorate minor to moderate symptoms of depression. In this regard, tryptophan-rich diets, diets rich in omega-3 fatty acids such as fish, olive oil, and Flax seed oil, whole grains, soy bean, vitamin B1, vitamin B6, folate, and vitamin B12 along with iron and vitamin D3 are highly significant for alleviating various symptoms of depression.
Personalized Medicine (Beyond PET Biomarkers)
Nova Science Publishers, New York, U.S.A has now released Personalized Medicine (Beyond PET Biomarkers), which is an extension of the authors recently published book Progress in PET Radiopharmaceuticals: Quality Control and Theranostics. In addition to recently-developed clinically-significant PET-RPs as biomarkers, this book describes various other emerging biotechnologies including: genomic medicine, nanotechnology, novel molecular biomarkers, and noninvasive imaging biotechnologies for early theranostics and personalised patient care, with minimum or no adverse effects. New therapeutic interventions including gene and cell therapies, pharmacogenomics, next generation sequencing, genome-wi...
Beyond Diet and Depression
Volume 2 offers in-depth knowledge about depression and its alleviation through dietary interventions as described briefly in Volume 1. This volume is intended for the benefit of the general public and the entire medical community interested in the effective clinical management of depression of diversified origin and to improve the therapeutic success through dietary interventions and other recently developed novel and disease-specific biomarkers for personalised treatment. This book is devoted particularly to provide recent knowledge about important healthy diets and their therapeutic potential in depression. In addition, it covers various clinically-significant aspects of disease-specific ...
Charnolophagy in Health and Disease
This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug ad...
The Charnoly Body
Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alope...
