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Phage Therapy: Past, Present and Future
Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and F...
Lactic Acid Bacteria in Foodborne Hazards Reduction
This book provides an overview of the physiological basis of lactic acid bacteria and their applications in minimizing foodborne risks, such as pathogens, heavy metal pollution, biotoxin contamination and food‐based allergies. While highlighting the mechanisms responsible for these biological effects, it also addresses the challenges and opportunities that lactic acid bacteria represent in food safety management. It offers a valuable resource for researchers, graduate students, nutritionists and product developers in the fields of food science and microbiology.
E. Coli Infections
Gram-negative Escherichia coli (E. coli) bacteria are the most numerous commensal aerobic germs located in the human colon. Diarrhea caused by E. coli pathogenic strains is a major cause of death in developing countries, especially the sub-Saharan and South Asian areas. Some strains cause diarrhea, and all of them may produce an infectious disease. This book includes ten chapters covering the main aspects of infections related to E. coli, their pathogenic mechanisms, treatments, and resistance to diverse antibiotics.
Advances in Synthetic Biology
This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
Anhydrobiosis
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Biofunctional Textiles and the Skin
In recent years the development of new technologies has permitted the production of 'functional' or 'smart' textiles. These fabrics are capable of sensing changes in environmental conditions or body functions and are adequately responding to them. They are able to absorb substances from the skin or to release therapeutic or cosmetic compounds. For instance, they can be used in underwear with an integrated cardio-online system or as textiles with carrier molecules. The focal point of interest in biofunctional textiles lies currently on the use of textiles supporting therapy and prevention in dermatology. This volume collects information about new trends in the interaction between textiles and the skin, particularly the development of antimicrobial finished textiles. It presents a selection of papers which will contribute to further consolidate the dialogue between dermatologists, allergologists, biomaterial scientists and textile engineers.
Process Integration in Biochemical Engineering
Process integration has been one of the most active research fields in Biochemical Engineering over the last decade and it will continue to be so if bioprocessing is to become more rational, efficient and productive. This volume outlines what has been achieved in recent years. Written by experts who have made important contributions to the European Science, Foundation Program on Process Integration in Biochemical Engineering, the volume focuses on the progress made and the major opportunities, and in addition on the limitations and the challenges in bioprocess integration that lie ahead. The concept of bioprocess integration is treated at various levels, including integration at the molecular, biological, bioreactor and plant levels, but also accounting for the integration of separation and mass transfer operations and biology, fluid dynamics and physiology, as well as basic science and process technology.
