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The lac Operon
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Genesis of the Salk Institute
This work is a personal account of the origins and early years of the Salk Institute for Biological Studies. Bourgeois crafts an engaging study that draws on her involvement with the Institute and on related archives, interviews, and informal conversations. The volume discusses the people who founded the Institute and built a home for renowned researchÑleading scientists of the time as well as non-scientists of stature in finance, politics, philanthropy, publishing, and the humanities. The events that brought people together, the historic backdrop in which they worked, their personalities, their courage and their visions, their clash of egos and their personal vanities are woven together in a rich, engaging narrative about the founding of a world-premier research institution.
Biochemical Actions of Hormones V12
Biochemical Actions of Hormones, Volume XII is a compendium of papers discussing aspects of molecular biology with regard to hormone action and to certain hormone receptors. One paper discusses the different approaches and strategies that are used in determining the amino acid sequence. The paper also describes the structural organization of polyprotein precursors such as the peptide chemistry approach or the nucleic acid approach. Another paper investigates the regulation of prolactin biosynthesis by peptide hormones as a model for peptidergic regulation of gene expression. The paper defines in detail which components of the biosynthetic machinery are being regulated by the polypeptide horm...
Research Grants
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Biological Cycles
Current Topics in Cellular Regulation, Volume 18: Biological Cycles covers topics on the events of molecular biology, cellular communication, and the merging of cell structure to biochemical function. The book discusses the ornithin-urea cycle; the cycles of glutathione metabolism and transport; and the role of multienzymatic proteins in mammalian pyrimidine biosynthesis. The text also describes the significance of interconvertible enzyme cycles in cellular regulation; regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle; replenishment of citric acid cycle intermediates by the purine nucleotide cycle in rat skeletal muscle. The control of a secondary pathway of ethanol metabolism by differences in redox state; the role of aldolase and fructose bisphosphatase in the control of gluconeogenesis and glycolysis; and the fructose 6-phosphate/fructose 1,6-bisphosphate cycle are also considered. The book further tackles the cycles in polysaccharide biosynthesis and other important biological cycles. Biologists, microbiologists, cellular biologists, and biochemists will find the book invaluable.
Advances in Protein Chemistry
Advances in Protein Chemistry
Current Topics in Cellular Regulation
Current Topics in Cellular Regulation, Volume 4 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into six chapters, this volume begins with an overview of the activity of ornithine transcarbamylase that catalyzes the condensation of carbamyl phosphate with ornithine. This text then presents and discusses the in vitro data that are available on the molecular interactions that govern the expression of lactose (lac) operon. Other chapters consider the bovine liver, which has been characterized in terms of molecular and kinetic characteristics. This book discusses as well the de novo synthesis of saturated fatty acids, which is catalyzed by two enzyme systems. The final chapter deals with the factors leading to glycogenolysis as it occurs in mammalian skeletal muscle. This book is a valuable resource for biologists and biochemists.
Eight Decades of General Linguistics
'Eight Decades of General Linguistics' offers the lectures of outstanding scholars including Otto Jesperson, Louis Hjelmslec, André Martinet, Uriel Weinreich, Noam Chomsky, and others held during the 18 conferences organized by the Permanent International Committee of Linguists.
