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Mechanisms of Adiponectin Action
The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin ha...
Metabolic Responses and Adaptations to Exercise
Worldwide, individuals are living longer. As such, the number of older adults in society is increasing. By 2050, it is estimated that there will be more than two billion individuals aged over 60. This aging population is associated with an anticipated increase in the burden of the leading causes of death in modern societies, including chronic and degenerative diseases that are largely driven by age-related declines in physiological function. Physical activity is an essential regulator of energy homeostasis and helps improve metabolic health. In fact, it is well known that regular exercise lowers the risk of a broad variety of health problems, such as cardiovascular disease, type 2 diabetes, and cancer in the aged. The beneficial effect of exercise is particularly evident in older people, but it is present in all stages of life, from children to the elderly. In this regard, regular exercise and physical activity are considered key first line strategies for a healthy life.
Computational Approaches in Biotechnology and Bioinformatics
Volume 1 of Computational Approaches in Bioengineering—Computational Approaches in Biotechnology and Bioinformatics—explores many significant topics of biomedical engineering and bioinformatics in an easily understandable format. It explores recent developments and applications in bioinformatics, biomechanics, artificial intelligence (AI), signal processing, wearable sensors, biomaterials, cell biology, synthetic biology, biostatistics, prosthetics, big data, and algorithms. From applications of biomaterials in advanced drug delivery systems to the role of big data, AI, and machine learning in disease diagnosis and treatment, the book will help readers understand how these technologies a...
My Mother was an Upright Piano
My Mother Was an Upright Piano builds on the strengths of Tania Hershman's first collection of short stories The White Road which was commended by the judges of the 2009 Orange Award for New Writers. Hershman's fiction is inspiring, thought-provoking and witty. Her economy with words cloaks her subtlety and power, and she is able to create characters with distinct voices and explore deep and sometimes disturbing relationships is just a few paragraphs of prose. Her writing style has a lyrical quality and often the meter of her work brings added resonance to her themes.
Il sognatore
L’ho cominciato a scrivere in un giorno di tristezza che mi era venuta nel non poter salutare una persona amica che partiva, mi ero assentato per prendere dell’acqua, ed ero arrivato dopo che il treno è partito, così ho fatto una storia che si svolge a MESTRE VENEZIA e finisce a TROMSO in NORVEGIA molto romantica e avvincente per un 3 ore di relax cosa posso dire di piu’ se non buona lettura.
Bulletin
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