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The Molecular Biology of Down Syndrome
This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.
The Neuropathology of Dementia
Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.
Evidence-based Dementia Practice
The era of therapeutic nihilism in dementia has ended, with the emergence of agents for symptomatic treatment, those that delay the course of the disease or prevent the onset of dementia, and new methods to manage symptoms. With the expansion of therapies, there is a clear danger of being overwhelmed by the volume of data. This book is designed to collect this information, distil what is relevant and reliable, and present it in a format that is useful to clinicians who manage and treat people with dementia. The book is designed to bring together the latest, best and practical evidence on all aspects of management, from diagnosis and therapy to social and ethical considerations. The editors are all dynamic clinicians involved in the care of patients with dementia and the evaluation of therapies. Two of the editors are the leaders of the Cochrane Collaboration for the examination of therapies for dementia. There are no other books that take such a practical and problem-oriented or approach to the diagnosis and management of dementia. Furthermore none but this can be described as truely evidence-based.
Genesis
None
Folding for the Synapse
Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
XHTML
Az XHTML a jelenlegi és jövőbeli dokumentumtípusok olyan családja, mely a HTML 4-es verzióját reprodukálja, részhalmazokra bontja és kibővíti. Az XHTML dokumentumtípus-család XML alapú és ennek megfelelően XML alapú felhasználói rendszerekkel való munkához lett tervezve. A könyv bemutatja az XHTML dokumentumcsalád tagjait, az XHTML 1.0-t, az XHTML Basic-et és az 1.1-es verziót, sőt megismerhetjük napjaink legfejlettebb, de még kiforratlan webes leírónyelvét, az XHTML 2.0-t is. Haszonnal forgathatják a könyvet azok is, akik még nem foglalkoztak az XML-lel, de a HTML-t már jól ismerik. Megtudhatjuk, hogyan térhetünk át a HTML-ről az XHTML-re, valamint a...
Neuroscience in Africa
This Research Topic covers some of the latest research on brain and behavior in health and disease in Africa. With its untapped resources and unique situations, “Neuroscience in Africa” has the potential to contribute to a better understanding of human brain function both in health and disease. The diverse African fauna display a range of specializations in brain structure/function relationships as a result of adaptations to the environment. Exploration of these may lead to insights into coping strategies which could be extrapolated to humans. Africa’s unique flora is being investigated for anti-inflammatory, antinociceptive, antioxidant, antiepileptogenic and neuroprotective properties to determine its potential for use in the treatment of human brain disorders. There is also research on neurodegenerative and infectious diseases, not only common to the global world, but also neglected tropical diseases and conditions which provide unique avenues of investigations in basic and translational neuroscience on highly debilitating disorders - and on the effects of pathogens and environmental toxins.
Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
The Cell Cycle in the Central Nervous System
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
