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Experimental & Clinical Epilepsy and Related Comorbidities
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Jasper's Basic Mechanisms of the Epilepsies
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous e...
Outcome of Childhood Epilepsies
The aim of this book is to take a critical look at what is known about outcome of childhood epilepsies, specifically evidence-based findings, and further clarify the direction of clinical and fundamental research for the future. At the time a diagnosis of epilepsy is made for a child, it is highly desirable to predict seizure control and social outcome several months or even years later. Determination of outcome is, however, complex and in order to confront this challenge, a number of simple questions should be addressed: What is to be predicted? This may be seizure control, remission with or without ongoing AED treatment, intractability, social outcome, quality of life, or a combination of the above. What is the purpose of attempting to predict outcome and who will use the information? How accurate is the prediction?
Epilepsy: Basic principles and diagnosis
Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.
Inflammation and Epilepsy: New Vistas
This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
Micromosaics
The art of mosaics is of ancient origin, enjoying its first great period during the Roman Empire and its second in eighteenth and nineteenth century Rome, when a flourishing craft developed in response to the Grand Tour. Affluent tourists provided the ideal market for views of Rome and images from Ancient History and mythology, painstakingly worked in tesserae - minute pieces of coloured enamel - a technique known as 'micromosaics.' Some of these were so intricate that one square inch could contain as many as 1,500 tesserae. The range of objects was enormous - from jewellery and snuffboxes to large pictures and tabletops. All of these forms and subjects are comprehensively represented in the Gilbert Collection. This book examine the collection through full-colour illustrations and detailed descriptions and commentaries. New research into the workshops and business practices of two significant Roman mosaicists derived from the archives of the Vatican Mosaic Workshops is detailed in an essay by Massimo Alfieri, while Judy Rudoe explores the techniques and materials of small-scale Roman micromosaic objects, illustrated with spectacular magnified photography.
Epilepsy
Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo
Febrile Seizures
Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book. The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, th...
