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The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. Are neurofibrillary tangles and senile plaques directly related to clinical symptoms, or are they epiphenomena that signal synaptic and neuronal loss? In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation Ipsen which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology. .
From materials science to integrated circuit development, much of modern technology is moving from the microscale toward the nanoscale. This book focuses on the fundamental physics underlying innovative techniques for analyzing surfaces and near-surfaces. New analytical techniques have emerged to meet these technological requirements, all based on a few processes that govern the interactions of particles and radiation with matter. This book addresses the fundamentals and application of these processes, from thin films to field effect transistors.
Here is the first book to discuss the current understanding of silver metallization and its potential as a future interconnect material for integrated circuit technology. With the lowest resistivity of all metals, silver is an attractive interconnect material for higher current densities and faster switching speeds in integrated circuits. Over the past ten years, extensive research has been conducted to address the issues that have prevented silver from being used as an interconnect metal. The authors provide details on a wide range of experimental, characterization, and analysis techniques. The book is written for students, scientists, engineers, and technologists in the fields of integrated circuits and microelectronics research and development.
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Includes appendices.
Early American Women Critics demonstrates that performances of various kinds - religious, political and cultural - enabled women to enter the human rights debates that roiled the American colonies and young republic. Black and white women staked their claims on American citizenship through disparate performances of spirit possession, patriotism, poetic and theatrical production. They protected themselves within various shields which allowed them to speak openly while keeping the individual basis of their identities invisible. Cima shows that between the First and Second Great Religious Awakenings (1730s–1830s), women from West Africa, Europe, and various corners of the American colonies self-consciously adopted performance strategies that enabled them to critique American culture and establish their own diverse and contradictory claims on the body politic. This book restores the primacy of religious performances - Christian, Yoruban, Bantu and Muslim - to the study of early American cultural and political histories, revealing that religion and race are inseparable.
Presenting papers from the 2013 annual meeting of The Minerals, Metals & Materials Society (TMS), this volume covers developments in all aspects of high temperature electrochemistry, from the fundamental to the empirical and from the theoretical to the applied.
This volume includes 14 papers from the National Academy of Engineering's Ninth Annual U.S. Frontiers of Engineering Symposium held in September 2003. The U.S. Frontiers meeting brings together 100 outstanding engineers (ages 30-45) to learn from their peers and discuss leading-edge technologies in a range of fields. The 2003 symposium covered these four areas: environmental engineering; fundamental limits of nanotechnology; counterterrorism technologies and infrastructure protection; and biomolecular computing. Papers in the book cover topics such as microbial mineral respiration; water-resource engineering, economics, and public policy; frontiers of silicon CMOS technology; molecular elect...