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Archaeal Cell Envelope and Surface Structures
Archaea and Bacteria have complex cell envelopes that play important roles in several vital cellular processes, including serving as a barrier that protects the cytoplasm from the environment. Along with associated proteinaceous structures, cell envelopes also ensure cell stability, promote motility, mediate adherence to biotic and abiotic surfaces, and facilitate communication with the extracellular environment. While some aspects of the biosynthesis and structure of the cell are similar to the three domains of life, archaeal cell envelopes exhibit several unique characteristics. Moreover, recent analyzes have revealed that many features of cell envelopes can vary greatly between distantly ...
Microbes from Hell
Patrick Forterre is a leading expert on archaea and thermophiles, and in Microbes from Hell (originally published as Microbes de l enfer by Belin, 2007) he offers an engaging, colorful overview of Archaea: single-celled microorganisms that were initially found in extreme habitats such as Yellowstone s volcanic hot springs. He starts with a history of Archaea s discovery and the conceptual revolution it sparked in our understanding of life s evolution; then, in the second chapter, he provides a personal account of his own search for thermophiles. In chapter three, Mr. Forterre discusses the challenges of living in high-temperature environments along with the ways in which thermophiles have adapted to them. In chapters four and five, he examines their relationships to other organisms as well as their role in the early evolution of life. Last, he presents the latest discoveries in thermophile research."
Biocommunication of Archaea
Archaea represent a third domain of life with unique properties not found in the other domains. Archaea actively compete for environmental resources. They perceive themselves and can distinguish between ‘self’ and ‘non-self’. They process and evaluate available information and then modify their behaviour accordingly. They assess their surroundings, estimate how much energy they need for particular goals, and then realize the optimum variant. These highly diverse competences show us that this is possible owing to sign(aling)- mediated communication processes within archaeal cells (intra-organismic), between the same, related and different archaeal species (interorganismic), and betwee...
Archaea
This volume provides an overview of well-established methods optimized for diverse archaeal model organisms and is a source of protocols facilitating access to the molecular and cellular biology characterization of these fascinating organisms. Chapters are divided into five parts detailing available genetic tools, molecular and cellular biology methods, strategies to study the ecophysiology of archaea, and classroom protocol. Each main thematic part is also introduced by future-oriented and authoritative primers. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Archaea: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.
Archaeal Virus-host Interactions
The work presented in this thesis provides novel insights in several aspects of the molecular biology of Archaea, Bacteria and their viruses. The archaeal virus Sulfolobus islandicus rod-shaped virus 2 (SIRV2), has a remarkable infection cycle. Infection with SIRV2 results in the formation of large virus associated pyramids (VAPs) on the host cell surface. The pyramids open during the final step of the infection cycle, to allow the release of virions. This virus release mechanism is unique. The VAPs are formed by self-assembly of one virus-encoded protein, PVAP. VAPs exist as discrete particles, and are baseless pyramids with heptagonal perimeter. The assembly process of the VAPs is describe...
Structural Insights Into the Mechanism of Archaellar Rotational Switching
Abstract: Signal transduction via phosphorylated CheY towards the flagellum and the archaellum involves a conserved mechanism of CheY phosphorylation and subsequent conformational changes within CheY. This mechanism is conserved among bacteria and archaea, despite substantial differences in the composition and architecture of archaellum and flagellum, respectively. Phosphorylated CheY has higher affinity towards the bacterial C-ring and its binding leads to conformational changes in the flagellar motor and subsequent rotational switching of the flagellum. In archaea, the adaptor protein CheF resides at the cytoplasmic face of the archaeal C-ring formed by the proteins ArlCDE and interacts wi...
Journey of the Mind: How Thinking Emerged from Chaos
Two neuroscientists reveal why consciousness exists and how it works by examining eighteen increasingly intelligent minds, from microbes to humankind—and beyond. Why do you exist? How did atoms and molecules transform into sentient creatures that experience longing, regret, compassion, and even marvel at their own existence? What does it truly mean to have a mind—to think? Science has offered few answers to these existential questions until now. Journey of the Mind is the first book to offer a unified account of the mind that explains how consciousness, language, self-awareness, and civilization arose incrementally out of chaos. The journey begins three billion years ago with the emergen...
Tessa Ever After
In this grippingly emotional New Adult novel from the author of Caged in Winter, what you want isn’t always what you need… Jason’s been living (and loving) the rich playboy lifestyle for five years, but now his parents are pressuring him to get involved in the family business. The last thing he wants is another obligation, but when his best friend moves out of state and asks Jason to look after his sister, he can’t just say no. Tessa had to grow up way too soon. After dealing with the aftermath of her parents’ deaths, then becoming a teenage mom, she knows the meaning of responsibility. Which is why, at twenty-two, she’s looking for so much more than a party boy. She’s looking for someone who can stand by her and her daughter…forever. A relationship between them is doomed from the start, but who says they can’t have a little fun? But as Jason gets closer to Tessa—and her daughter—fun starts to turn into something else… Something Jason’s not sure he’s ready for.
Late in the Day
'Unflinching, intelligent and fascinating' Marian Keyes The lives of two close-knit couples are irrevocably changed by an untimely death in this Sunday Times bestselling novel Alex and Christine and Zach and Lydia have been inseparable since their twenties. From student house-shares and grubby pubs to proper homes and grown-up careers, the two couples' lives have been interlinked for decades. Then one evening, Alex and Christine receive a call from a distraught Lydia. Zach is dead. Inconsolable, Lydia moves in with Alex and Christine. But instead of their loss bringing them closer, the three of them find that love and sorrow give way to anger and bitterness as old entanglements and resentments rise from the past. 'A fine-grained novel of friendship, loss and jealousy' Sunday Times, *100 Great 21-Century Novels*
Raw Redemption
Disgraced cop Henrik Vance is having a shit year. Banished to a derelict undercover squad, he’s been tasked with hunting down the daughter of Chicago’s most dangerous criminal. His obsession with saving the beautiful girl destroyed his career. And this time, it might cost his life. Ailish O’Kelly doesn’t need a hero. She’ll save herself from her father’s violent criminal dynasty, thank you very much. Unfortunately, the sexy as sin cop who crashes her hideout isn’t hearing reason—especially not after the kiss that becomes much more. His boss wants her as an informant. Ailish wants Henrik to keep whispering filthy things against her skin. But she knows too well the evil they’re up against, and when it comes down to protecting the man who owns her body and soul, she only has one choice... Each book in the Crossing the Lines series is a standalone, full-length story that can be enjoyed out of order. Series Order: Prequel Novella: His Risk to Take Book .5: Riskier Business Book 1: Risking it All Book 2: Up In Smoke Book 3: Boiling Point Book 4: Raw Redemption
