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Head formation requires the well-orchestrated and harmonised development of various tissues and organs within the craniofacial complex. A big variety of signaling pathways are involved in this process by controlling cell proliferation, migration, differentiation, tissue morphogenesis, homeostasis and regeneration. Deregulation and malfunction of these signaling molecules may lead to mild or severe craniofacial pathologies. This eBook is a collection of articles dealing with a variety of important signals involved in the control of developmental and pathological events of craniofacial organs and tissues. These recent advances show the importance of signaling pathways in craniofacial physiology and pathology and generate important new knowledge aiming the development of new pharmaceutical products that mimic and/or block the actions of specific molecules.
Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete d...
This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.
Nanomedicine-the application of nanotechnology to health sciences-has the potential to address many important medical problems by exploiting the advanced physicochemical characteristics of nanostructured materials and devices. It can revolutionize conventional medicine by offering cutting-edge developments in the processes of diagnosing, treating,
More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased bra...
Dental and craniofacial treatments are actually based on advances in biomaterials, tissue engineering and nanotechnology sciences. These developments brought considerable improvements on biomaterials commonly used in dental clinics. However, there is still a medical need for innovative techniques and materials for a controllable and efficient regeneration/repair of damaged craniofacial tissues and teeth. The novel biomaterials, imaging techniques, diagnostic and technological tools may offer thrilling perspectives for alternative treatments in dentistry.
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by...
Das tiefste Verständnis der Zellen des oralen Systems wird durch die Entschlüsselung ihrer Kommunikation erreicht. Wenn es erst einmal möglich ist, ihre Sprache zu verstehen, lässt sich vielleicht lernen, mit ihnen zu sprechen und ihre Aktionen zu steuern. Das vorliegende Buch wurde von 47 weltweit anerkannten Fachleuten verfasst. Mindestens eine Expertin oder ein Experte jeweils aus der Klinik und aus der Grundlagenwissenschaft haben zusammen an einem Kapitel gearbeitet. Zuverlässig und mit hoher Aktualität dokumentieren sie den aktuellen Forschungsstand. Jenseits der klassischen Zelltypen, die im ersten Teil des Buches in alphabetischer Reihenfolge vorgestellt werden, geht es im zweiten Teil in vier weiteren Kapiteln um generische Organ- oder Modellsysteme der zellulären Kommunikation. Dieses Buch – begleitet von einer Augmented Reality (AR) App, mit der der Prozess des Knochenabbaus virtuell miterlebt werden kann – soll helfen, eine Vision zu entwickeln, wie wir Gewebe regenerieren und Krankheiten heilen können, indem wir die Sprache der Zellen steuern. Die Publikation zeigt uns, in welche Richtung Forschung und Therapie in Zukunft gehen werden.
This new, updated edition of Dental Pathology will assist in the recognition and diagnosis of gross dental abnormalities. Topics covered include disturbances in tooth formation, acquired dental diseases, including caries and its sequelae, periodontal disease, and odontogenic tumours. Practically applicable knowledge is provided on the histology and histopathology of the changes that are seen in diseases of the dental and periodontal tissues, and attention is also paid to the histological alterations induced by dental treatment. Compared with the first edition, ca. 50% more illustrations are included and more information is provided on diagnostically difficult cases. This work will be an invaluable companion for dental practitioners who need to make diagnoses in such cases and will also be of value for surgical pathologists, clinical geneticists, and oral and maxillofacial surgeons.