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Molecular Targeted Therapy of Lung Cancer
This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.
Successful Drug Discovery, Volume 3
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
Cancer Neurology in Clinical Practice
This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted m...
Privileged Structures in Drug Discovery
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book...
Integrated Restoration of Forested Ecosystems to Achieve Multiresource Benefits
"A primary mission of the U.S. Department of Agriculture Forest Service is multiple resource management, and one of the emerging themes is forest restoration. The National Silviculture Workshop, a biennial event co-sponsored by the Forest Service, was held May 7-10, 2007, in Ketchikan, Alaska, with the theme of "Integrated Restoration of Forested Ecosystems to Achieve Multiresource Benefits." This proceedings presents a compilation of state-of-the-art silvicultural research and forestry management papers that demonstrates integrated restoration to yield multiple resource benefits. These papers highlight national perspectives on ecosystem services, forest restoration and climate change, and regional perspectives on forest restoration and silvicultural practices to achieve multiple resource benefits from researchers and forest practitioners working in a broad array of forest types in the United States."
Seed Bank Response to Prescribed Fire in the Central Appalachians
Pre- and post-treatment seed-bank characteristics of woody species were compared after two prescribed fires in a mesic mixed-oak forest in the central Appalachians. Nineteen woody species were identified from soil samples. Mean species richness declined but evenness did not after prescribed burning. The seed bank was dominated by black birch, yellow-poplar, blackberry, grapevine and Hercules club before burning. Following burning, the median density of seed bank propagules declined by 45 percent. Black birch, yellow-poplar, and grapevine declined by 69, 56, and 40 percent, respectively. The results illustrate the importance of the seed bank as a robust source of non-oak regeneration in mixed-oak forests and of the potential effect of fire altering it.
