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Structure and Function of Glutathione S-Transferases
Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.
Protein Purification Protocols
The first edition of Protein Purification Protocols (1996), edited by Professor Shawn Doonan, rapidly became very successful. Professor Doonan achieved his aims of p- ducing a list of protocols that were invaluable to newcomers in protein purification and of significant benefit to established practitioners. Each chapter was written by an ex- rienced expert in the field. In the intervening time, a number of advances have w- ranted a second edition. However, in attempting to encompass the recent developments in several areas, the intention has been to expand on the original format, retaining the concepts that made the initial edition so successful. This is reflected in the structure of this se...
Protein Purification Protocols
Hans Neurath has written that this is the second golden era of enzymology {Protein Science [1994], vol. 3, pp. 1734—1739); he could with justice have been more general and referred to the second golden age of protein chemistry. The last two decades have seen enormous advances in our understanding of the structures and functions of pro teins arising on the one hand from improvements and developments in analytical techniques {see the companion volume, Basic Protein and Peptide Protocols, in this series) and on the other hand from the tech nologies of molecular genetics. Far from turning the focus away from protein science, the ability to isolate, analyze, and express genes has increased inte...
Naked Truths
Critically up-to-date and theoretically informed Epilogue by Natalie Boymel Kampen - well known specialist Gender/Sexuality/Women are hot research topics Also studied on courses in ancient history and classical art/archaeology Hb reprinted and very well received
Glutathione S-transferases and Drug Resistance
The proceedings of the 3rd International GST Conference held at the Royal College of Physicians, Edinburgh, on 20-30 August 1989. The conference was divided into five sessions - enzymology, toxication, control of expression, drug resistance and clinical applications of GST.
Drug Metabolism
With its roots in the last century and currently exploiting the technology of today, the science of drug metabolism has made significant contributions to our understanding of chemico-biological interactions. This book reviews past successes and failures within the science and attempts to predict new directions. Each of the chapters of this book deals with an aspect of xenobiotic metabolism which has featured prominently in the development of the discipline. The volume is testimony to the breadth and depth of research into xenobiotic metabolism and covers the chemistry and enzymology of xenobiotic metabolism, enzyme modeling and structure activity relationships, pharmacokinetics, the use of r...
