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Encyclopedia of Molecular Pharmacology
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Adhesion G Protein-coupled Receptors
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Vasopressin and Oxytocin
This monograph provides a comprehensive overview of recent advances in the field of vasopressin and oxytocin. In the summer of 1997, scientists from over 20 countries congregated in Montreal for the 1997 World Congress of Neurohypophysial Hormones, a conference that united the fields of vasopressin, neurohypophysis and oxytocin in a single joint meeting that gave rise to the present book. The organization of a joint meeting was prompted by several recent developments. Specifically the molecular characterization of the vasopressin/oxytocin receptor family made it mandatory to adopt an integrated view and to discuss the vasopressin/oxytocin ligand/receptor family as a whole. To ensure em phasi...
Origins of Human Neuropathology: The Significance of Teneurin-Latrophilin Interaction
We are delighted to introduce this new special issue on “The Origins of Neuropathology: The Roles of Teneurins and Latrophilins”. Although the title may seem particularly bold, and indeed, perhaps presumptuous, we the editors, think our title well warranted based on the findings and interpretation provided by a dedicated group of researchers who have developed this field over the last 25 years. In this publication, we introduce the readers to researchers whom have pioneered this field, and those whom have played an essential role in developing this research direction. Now, together, their combined work have elucidated a novel ligandreceptor network that evolved during the earliest period...
G Protein-Coupled Receptors
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
Patterns of Human Growth
Discusses the biocultural and evolutionary factors that direct growth, and intrinsic and extrinsic factors affecting individual development.
Chance in Evolution
The first book to synthesize scientific and philosophical work on chance, this edited volume brings together leading biologists, philosophers of science, and historians of science, who collectively explore the role that chance plays or doesn t play, as the case may be in evolution. The first part of the volume places chance in historical context and explores how Darwin, along with his contemporaries, understood chance in addition to its related concepts; how these various concepts changed as Darwin s theory of evolution by natural selection developed into the Modern Synthesis; and how the chanciness of Darwinian theory affected theological resistance to it. The second part explores the impor...
Braintrust
What is morality? Where does it come from? And why do most of us heed its call most of the time? In Braintrust, neurophilosophy pioneer Patricia Churchland argues that morality originates in the biology of the brain. She describes the "neurobiological platform of bonding" that, modified by evolutionary pressures and cultural values, has led to human styles of moral behavior. The result is a provocative genealogy of morals that asks us to reevaluate the priority given to religion, absolute rules, and pure reason in accounting for the basis of morality. Moral values, Churchland argues, are rooted in a behavior common to all mammals--the caring for offspring. The evolved structure, processes, a...
Reviews of Physiology, Biochemistry and Pharmacology
In this volume of Reviews there are three outstanding articles, one on phspholipase D, an enzyme that is widely distributed in bacteria, protozoa, fungi, plants and animals. Phospholipase D carries out a transphosphatidylation reaction, which is unique to this enzyme. This review is focussed on mammalian PLDs. The second review deals with endotoxin tolerance, the term which describes the phenomenon that immune responses and metabolic changes are mitigated after repeated LPS administration. The third article summarizes the current knowledge relevant to understanding the molecular basis of GPCR function and focusses on the underlying mechanisms of GPCR malfunctions responsible for diferent human diseases.
Handbook of Chemical and Biological Warfare Agents, Volume 2
The Handbook of Chemical and Biological Warfare Agents, Volume 2: Pathogens, Mid-Spectrum, and Incapacitating Agents, Third Edition provides rapid access to key data to response professionals and decision-makers on a broad range of agents and pathogens. This volume presents information on a wide range of chemical and biological agents. Chemical agents detailed in this volume are those that were developed specifically for their non-lethal potential. The biological agents described are militarily significant pathogens that could be weaponized to pose a threat to people, animals, or crops and other agricultural interests. Mid-spectrum agents, materials that do not fit clearly into either the Ch...
