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Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Fur...
Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators whic...
**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR** From the dawn of life itself, every being that has ever lived owes its existence to the cell. 'Will leave you in awe' Guardian The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether. Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better. 'Profound...As big a topic as life itself' The Times 'Medical magic' Daily Telegraph 'Vast...important...optimistic' Mail on Sunday
Aan het einde van de zeventiende eeuw doen de Engelse geleerde Robert Hooke en de Nederlander Antoni van Leeuwenhoek een ontdekking die de wetenschap voorgoed verandert. Door hun zelfgemaakte microscopen zien ze dat organismen complexe verzamelingen zijn van minuscule, opzichzelfstaande systemen. Ons hele wezen – ons lichaam, onze organen – is samengesteld uit deze eenheden. Hooke doopt ze ‘cellen’. Deze nieuwe kijk op het menselijk lichaam leidt de geboorte in van de moderne geneeskunde, waarbij aandoeningen worden beschouwd als het samenspel van zich afwijkend gedragende cellen en artsen proberen die te behandelen door cellen te manipuleren. Zo ontstaat een nieuwe mens. In Het lied van de cel neemt Siddhartha Mukherjee ons mee in de wereld van de cellen en verweeft hij de verhalen van wetenschappers, artsen en patiënten met zijn eigen ervaringen als arts en onderzoeker. Net als in zijn twee voorgaande boeken biedt hij de lezer een panoramische én intieme blik op wat het betekent om mens te zijn.
Sesudah mikroskop dibuat untuk pertama kali pada akhir 1600-an, para ahli menggunakannya untuk meneliti makhluk hidup, dan mereka melihat bahwa seluruh kehidupan terbentuk dari satuan-satuan kecil yang utuh dan mampu mengatur diri sendiriÑsel. Penemuan sel mengubah bidang biologi dan kedokteran untuk seterusnya. Tubuh kita, organ kita, diri kitaÑjantung, darah, otakÑdibangun dari sel-sel. Pengetahuan bahwa tubuh manusia adalah ekosistem sel melahirkan kedokteran baru yang didasari manipulasi sel untuk menyembuhkan. Berbagai gejala dan penyakit dipahami sebagai gangguan fungsi sel atau sistem sel. Oleh karena itu dikembangkan pula berbagai penanganan dan terapi berbasis selÑtransfusi dara...
Skin is the largest organ of the body and is necessary for survival, since it performs many functions such as providing a physical barrier to the external environment, sensation, retention of normal hydration and thermal regulation. Significant skin loss is associated with high mortality and morbidity in the acute phase, and with physically and cosmetically drastic scarring in the long term. Although there are a number of tissue-engineered products in the clinic that are used as skin substitutes to promote healing of traumatic burn and diabetic wounds, yet they lack several important functions including those provided by the appendages such as the hair follicles, sebaceous and sweat glands. ...
The field of stem cell biology is expanding with a continued surge of new information related to its applications. Over past few years, stem cells have been extensively used in cell therapy, tissue engineering, in vitro drug testing among others. At the moment there is no single book available which comprehensively describes the significance of various application of stem cells derived from embryonic and adult sources from lab to clinics. In this edited volume, we discuss basics and advanced topics of stem cells to help researchers, students and professional find the most important information in a single source of updated information about stem cells and relevant applications. This book is divided in 12 chapters and covers topics such as in vitro cell culture, 3D cell culture, cell therapy, tissue engineering, cell factory, cell functionality, in vitro drug testing, organ development, autologous transplantation, allogeneic transplantation, adult stem cells, multipotent stem cells, induced pluripotent stem cells, a pluripotent and embryonic stem cells.