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Principles and Practice of Clinical Virology
The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates. This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included. There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.
Gastroenteritis Viruses
This important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections. Readers will also find an overview of gastroentitis vaccines, their structure and molecular biology, as well as the basic pathology of infection, epidemiology and surveillance. Provides an interdisciplinary approach, offering contributions from basic and clinical research Discusses the prevention and treatment of regimes Includes an overview of gastroentitis vaccines
Viral Gastroenteritis
Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis provides a comprehensive review of research on viruses causing acute gastroenteritis in infants and young children, including coverage of rotaviruses, human caliciviruses, astroviruses, enteric adenoviruses, and viruses causing gastroenteritis more rarely. Includes general chapters on gastrointestinal physiology and pathophysiology, gastrointestinal immune mechanisms, immunodeficiencies and host genetics influencing susceptibility to viral gastroenteritis, and therapeutic and preventative approaches. The book also includes special sections on virus particle structures, replication cycles, pathogenesis, immunology, epidemiology, a...
Viral Gastroenteritis
Rapid progress has been made in basic research of gastroenteritis viruses as well as their diagnosis and epidemiology, due to advent of highly sensitive and specific molecular detection techniques to analyse clinical materials. It is at the intersection of basic and applied clinical virology that this book wishes to make a contribution, directed towards the molecular analysis of viruses causing gastroenteritis as well as aspects of their pathogenesis, diagnosis, treatment, epidemiology, and vaccine-related research. The main emphasis is on data relating to rotaviruses, caliciviruses, astroviruses, and enteric adenoviruses. In addition, aspects of research on viruses less frequently causing diarrhoea (picornaviruses, toroviruses, picobirnaviruses, a.o.) are also presented.
Advances in Virus Research
- Among the topics covered are: - Poliovirus assembly and incapsidation of genomic RNA - HIV type 1 reverse transcriptase - Mechanisms of persistence and associated disease - Genome rearrangements of rotaviruses - Luteoviruses - Hepadnaviruses - Iridoviruses
Clinical Applications of Capillary Electrophoresis
In Clinical Applications of Capillary Electrophoresis, Stephen Palfrey brings together for first time a collection of detailed capillary electrophoresis protocols designed exclusively for clinical applications. Written by the leading scientists who have often perfected these methods in their own laboratories, the protocols furnish new and more powerful assays for many routine serum and blood tests now regularly performed in clinical laboratories, including urine protein analysis, hemoglobin separation, and the detection of CSF proteins, lipoproteins, myoglobin, cryoglobulins, HbA1c, and cathepsin. The protocols offered for DNA studies include double-stranded DNA analysis, the prenatal diagno...
Cumulative Subject Index
This volume gives the index of Volumes 25-47 as a handy reference to the contents. The series is aimed at virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers.
Gene Therapy of Cancer
Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized...
Antiviral Methods and Protocols
This latest addition to the Methods in Molecular Medicine series, Anti- ral Methods and Protocols, is opportune because there is an increasing int- est in discovering compounds that are effective against both chronic and acute viral infections. A number of the methods described in the volume are unp- lished and their inclusion indicates the speed at which this field is moving. This volume is not a review but each chapter contains methods validated by the experts who have spent time in developing the protocols. The hallmark of this series is the comprehensive way in which the me- ods are described, which includes a list of all the reagents needed for each protocol. Of importance is the section on tips and pitfalls that the authors have discovered while developing their protocols. The manual itself is designed to be used by researchers in universities and industry who are familiar with a range of biological techniques but who want to set up quickly a novel assay system. We encourage a dialog between readers and authors, which may also result in useful collaborations.
