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Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Following its well-received predecessor, this book offers an essential guide to chemists for understanding fluorine in spectroscopy. With over 1000 compounds and 100 spectra, the second edition adds new data – featuring fluorine effects on nitrogen NMR, chemical shifts, and coupling constants. • Explains how to successfully incorporate fluorine into target molecules and utilize fluorine substituents to structurally characterize organic compounds • Includes new data on nitrogen NMR, focusing on N-15, to portray the influence of fluorine upon nitrogen NMR chemical shifts and coupling constants • Expands on each chapter from the first edition with additional data and updated discussion from recent findings • "The flawless ordering of material covered in this stand-alone volume is such that information can be found very easily." – Angewandte Chemie review of the first edition, 2010
Preface... Table of Contents... Contributing Authors... Part I Introduction 1. Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies Andreas Pohlmann, Susan J. Back, Andrea Fekete, Iris Friedli, Stefanie Hectors, Neil Peter Jerome, Min-Chi Ku, Dario Livio Longo, Martin Meier, Jason M. Millward, João S. Periquito, Erdmann Seeliger, Suraj D. Serai, Sonia Waiczies, Steven Sourbron, Christoffer Laustsen, and Thoralf Niendorf Part II Animal Models, Preparation, Monitoring, and Physiological Interventions 2. Animal Models of Renal Pathophysiology and Disease Adam Hosszu, Tamas Kaucsar, Erdmann ...
Sustainability Appraisal is a sourcebook of the state-of-the-art of this rapidly emerging and diversifying area. It draws on a wealth of international experiences and approaches to illustrate the status and scope of Sustainability Appraisal/Assessment (SA) This comprehensive guide highlights how SA can be used to analyse and integrate the key environmental, social and economic pillars of sustainability into decision-making at all levels, from policy to project to investment, by government, business and industry, or international organizations. Distilling both published and unpublished materials, and with contributions from a range of leading experts, organizations and agencies, this book will be of significant value to professionals everywhere who are in need of a solid, reference guide to what constitutes SA practice and, more importantly, how and when it can be applied.
This unique sourcebook provides a global, state-of-the-art review of the rapidly evolving field of strategic environmental assessment (SEA) that is intended to serve as a baseline for the work of an OECD Task Team on SEA and a UNEP initiative on integrated planning and assessment. It describes trends in application and experience in different contexts worldwide, providing in-depth coverage of the status of SEA systems, and practice in developed, transitional and developing countries by a range of development agencies. The book draws on a large body of published and unpublished material, and contributions from a wide range of individual experts, organizations and agencies. It provides an unparalleled and invaluable understanding of the emerging scope and potential of SEA and describes how, when and where it is being used. The sourcebook includes a probing review of concepts, terminology, approaches and tools of SEA, and a comparative analysis of the different types of existing SEA systems. The volume also contains many case examples illustrating SEA practice in different countries and contexts, a full set of references and a number of appendices containing source materials.